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Your Position: Home > TDP-43

TDP-43

Brief Information

Name:TAR DNA binding protein 43
Target Synonym:TAR DNA-binding protein 43,TARDBP,TAR DNA Binding Protein,TDP43,TAR DNA-Binding Protein-43,ALS10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
TD3-H5145 Human Human TDP-43 Protein, His Tag
TD3-H5145-structure
TD3-H5145-sds
ACRO Quality

Part of Bioactivity data

TD3-H5145-MALS-HPLC
TDP-43 ELISA

Immobilized Human TDP-43, His Tag (Cat. No. TD3-H5145) at 1 μg/mL (100 μL/well) can bind Anti-TDP43 Antibody with a linear range of 0.2-3 ng/mL (QC tested).

Protocol

Synonym Name

TAR DNA-binding protein 43

Background

TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member.  involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMDX-2011P AMDX2011P; AMDX-2011P Phase 2 Clinical Amydis Inc Cerebral Amyloid Angiopathy; Glaucoma, Open-Angle; Parkinson Disease; Alzheimer Disease; Amyotrophic Lateral Sclerosis Details
AB-14 AB-14 Phase 1 Clinical Autotac Bio Inc Amyotrophic Lateral Sclerosis Details
Monepantel PPL-1; NUZ-001 Phase 1 Clinical PharmAust Ltd Motor Neuron Disease; Neoplasms Details

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