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KLRG1

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Part of Bioactivity data

KL1-C5269-SPR
 KLRG1 SPR

Human E-Cadherin, Fc Tag, premium grade (Cat. No. ECD-H5250) immobilized on CM5 Chip can bind Cynomolgus KLRG1 Protein, Fc Tag (Cat. No. KL1-C5269) with an affinity constant of 4.00 μM as determined in a SPR assay (Biacore 8K) (QC tested).

KL1-C5243-SPR
 KLRG1 SPR

Human E-Cadherin, Fc Tag, premium grade (Cat. No. ECD-H5250) immobilized on CM5 Chip can bind Cynomolgus KLRG1 Protein, His Tag (Cat. No. KL1-C5243) with an affinity constant of 2.38 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

KLRG1

Background

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.

Clinical and Translational Updates

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