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Brief Information

Name:Endothelin receptor type A
Target Synonym:Endothelin Receptor Type A,EDNRA,ETA-R,Endothelin-1 receptor,hET-AR,ETRA,ET-A,ETA,Endothelin-1-Specific Receptor,Endothelin Receptor Subtype A,G Protein-Coupled Receptor,ETAR,MFDA,Receptor, Endothelin A
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
EDA-H52P8 Human Human EDNRA Full Length Protein (VLP)
ACRO Quality

Part of Bioactivity data


Immobilized Human EDNRA Full Length Protein-VLP (Cat. No. EDA-H52P8) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human EDNRA antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Clazosentan Sodium Ro-61-1790; ACT-108475; AXV-034; VML-588; AXV-034343 Approved F. Hoffmann-La Roche Ltd Pivlaz Japan Subarachnoid Hemorrhage; Vasospasm, Intracranial; Cerebral Infarction; Brain Ischemia Idorsia Pharmaceuticals Ltd 2022-01-20 Brain Ischemia; Aneurysm; Vasospasm, Intracranial; Subarachnoid Hemorrhage; Cerebral Infarction Details
Macitentan/Tadalafil Approved Actelion Pharmaceuticals Ltd OPSYNVI United States Pulmonary Arterial Hypertension Actelion Pharmaceuticals Us Inc 2024-03-22 Pulmonary Arterial Hypertension Details
Ambrisentan LU-208075; BSF-208075; GSK-132576A Approved Abbott Laboratories Letairis, Volibris, 凡瑞克 United States Pulmonary Arterial Hypertension Gilead Sciences Inc 2007-06-15 Acute Kidney Injury; Anemia, Sickle Cell; Hepatorenal Syndrome; Vascular Diseases; Pulmonary Arterial Hypertension; Thromboembolism; Hypertension; Hypoxia; Ascites; Hypertension, Pulmonary; Sarcoidosis; Scleroderma, Systemic; Hypertension, Portal; Idiopathic Pulmonary Fibrosis; Fibrosis; Coronavirus Disease 2019 (COVID-19); Liver Cirrhosis Details
Sparsentan RE-021; PS-433540; BMS-346567 Approved Bristol-Myers Squibb Company Filspari United States Glomerulonephritis, IGA Travere Therapeutics Inc 2023-02-17 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Glomerulonephritis, IGA; Kidney Diseases; Vasculitis; Autoimmune Diseases; Nephrosis, Lipoid; Hypertension; Immune System Diseases; Glomerulosclerosis, Focal Segmental; Cardiovascular Diseases; Nephritis, Hereditary; Glomerulonephritis Details
Bosentan Hydrate ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039 Approved F. Hoffmann-La Roche Ltd Stayveer, 全可利, Tracleer United States Pulmonary Arterial Hypertension Actelion Pharmaceuticals Ltd 2001-11-20 Pulmonary Fibrosis; Heart Defects, Congenital; Diabetes Mellitus; Anemia, Sickle Cell; Persistent Fetal Circulation Syndrome; Ulcer; Sleep Apnea Syndromes; Glaucoma; Pulmonary Arterial Hypertension; Hypertension; Hepatopulmonary Syndrome; Hypertension, Pulmonary; Lung Diseases, Interstitial; Sarcoidosis; Liver Cirrhosis; Chronic thromboembolic pulmonary hypertension; Fibrosis; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Diabetes Mellitus, Type 2; Heart Septal Defects, Atrial Details
Macitentan ACT-064992; Actelion-1; JNJ-67896062 Approved Actelion Pharmaceuticals Ltd Zependo, Opsumit, 傲朴舒 United States Pulmonary Arterial Hypertension Actelion Pharmaceuticals Us Inc 2013-10-18 Hypertension, Pulmonary; Pulmonary Embolism; Heart Failure; Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic; Chronic thromboembolic pulmonary hypertension; Glioblastoma; Lung Diseases, Interstitial; Thromboembolism; Pulmonary Arterial Hypertension; Eisenmenger Complex; Ulcer; Anemia, Sickle Cell; Chronic Disease; Heart Defects, Congenital Details
Aprocitentan ACT-132577; AC-080; JNJ-2820 Approved Idorsia Pharmaceuticals Ltd, Actelion Pharmaceuticals Ltd TRYVIO United States Hypertension Idorsia Pharmaceuticals Ltd 2024-03-19 Hypertension; Hepatic Insufficiency; Essential Hypertension; Renal Insufficiency, Chronic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Zibotentan/Dapagliflozin Phase 3 Clinical Astrazeneca Ab, AstraZeneca global R & D (China) Co Ltd Albuminuria; Kidney Diseases; Renal Insufficiency, Chronic Details
Atrasentan ABT-627; A-147627; A-1476271; ABT-147627; (+)-A-127722; Abbott-147627 Phase 3 Clinical Abbvie Inc Kidney Neoplasms; Ovarian Neoplasms; Glomerulonephritis, IGA; Abdominal Neoplasms; Kidney Diseases; Central Nervous System Neoplasms; Brain Neoplasms; Glomerulosclerosis, Focal Segmental; Prostatic Neoplasms; Diabetic Nephropathies; Renal Insufficiency, Chronic; Fallopian Tube Neoplasms; Adenocarcinoma; Nephritis, Hereditary; Neoplasm Metastasis; Diabetes Mellitus Details
Patecibart GMA-301; GMA-301-A; GMA-301-B Phase 2 Clinical Gmax Biopharm Llc Pulmonary Arterial Hypertension Details
SC-0062 SC-0062 Phase 2 Clinical Shijiazhuang Zhikang Hongren New Drug Development Co Ltd Glomerulonephritis, IGA; Altitude Sickness; Kidney Diseases; Pulmonary Arterial Hypertension; Diabetic Nephropathies Details
Zibotentan ZD-4054; AZD-4054 Phase 2 Clinical Astrazeneca Plc Prostatic Neoplasms; Neoplasm Metastasis; Scleroderma, Limited; Carcinoma, Non-Small-Cell Lung; Peripheral Arterial Disease; Lung Neoplasms; Renal Insufficiency, Chronic; Hepatic Insufficiency; Colorectal Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Kidney Diseases; Hypertension, Portal; Small Cell Lung Carcinoma; Scleroderma, Systemic; Liver Cirrhosis; Intermittent Claudication; Solid tumours; Microvascular Angina Details
BQ-123 CGS-26343; BQ-123; PMZ-2123 Phase 1 Clinical Midwestern University Hypertension, Pulmonary; Heart Failure; ST Elevation Myocardial Infarction; Pain; Diabetic Ketoacidosis; Coronary Artery Disease; Proteinuria; Metabolic Syndrome; Hypoxia, Brain; Hypertension; Cardiovascular Diseases; Renal Insufficiency, Chronic; Multiple System Atrophy; Pure Autonomic Failure Details
GMA-131 GMA-131 Phase 1 Clinical Gmax Biopharm Llc, Gmaxx Biologics Ltd Diabetic Nephropathies Details
SAL-0120 SAL0120; SAL-0120 Phase 1 Clinical Shenzhen Salubris Pharmaceuticals Co Ltd Glomerulonephritis, IGA; Hypertension; Essential Hypertension Details

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