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Your Position: Home > Angiopoietin-like 3

Angiopoietin-like 3

Brief Information

Name:Angiopoietin like 3
Target Synonym:Angiopoietin Like 3,Angiopoietin 5,UNQ153/PRO179,Angiopoietin-5,Angiopoietin-like protein 3,ANGPT5,ANG-5,Angiopoietin-Related Protein 3,Angiopoietin-Like 3,FHBL2,ANL3,ANGPTL3
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
AN3-H5253 Human Human Angiopoietin-like 3 / ANGPTL3 Protein, Fc Tag
AN3-H5253-structure
AN3-H5253-sds
AN3-H52H3 Human Human Angiopoietin-like 3 / ANGPTL3 Protein, His Tag
AN3-H52H3-structure
AN3-H52H3-sds
AN3-M52H3 Mouse Mouse Angiopoietin-like 3 / ANGPTL3 Protein, His Tag
AN3-M52H3-structure
AN3-M52H3-sds
AN3-H82E7 Human Biotinylated Human Angiopoietin-like 3 / ANGPTL3 Protein, His,Avitag™
AN3-H82E7-structure
AN3-H82E7-sds
AN3-H5226 Human Human Angiopoietin-like 3 / ANGPTL3 Protein, His Tag
AN3-H5226-structure
AN3-H5226-sds
ACRO Quality

Part of Bioactivity data

AN3-H52H3-ELISA
Angiopoietin-like 3 ELISA

Immobilized Human Angiopoietin-like 3, His Tag (Cat. No. AN3-H52H3) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human ANGPTL3 Antibody, Human IgG1 with a linear range of 0.5-2 ng/mL (QC tested).

Protocol
AN3-H5253-ELISA
Angiopoietin-like 3 ELISA

Immobilized Human Angiopoietin-like 3 Protein, Fc Tag (Cat. No. AN3-H5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human ANGPTL3 Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

Protocol

Synonym Name

ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2

Background

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Evinacumab REGN-1500 Approved Regeneron Pharmaceuticals Inc Evkeeza United States Hypercholesterolemia; Homozygous familial hypercholesterolemia Regeneron Pharmaceuticals Inc 2021-02-11 Homozygous familial hypercholesterolemia; Hypertriglyceridemia; Hypercholesterolemia; Metabolic Diseases Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SHR-1918 SHR-1918; SHR1918 Phase 3 Clinical Beijing Suncadia Medicine Co Ltd Homozygous familial hypercholesterolemia; Hyperlipidemias Details
Zodasiran ARO-ANG3; ARO-ANG33; VSA-003 (Arrowhead Pharmaceuticals) Phase 3 Clinical Roche Ltd Hypertriglyceridemia; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Dyslipidemias; Hyperlipoproteinemia Type II Details
LNA-043 LNA-043 Phase 2 Clinical Novartis Pharma Ag Knee Injuries; Osteoarthritis, Knee; Osteoarthritis Details
Vupanorsen ISIS-703802; PF-07285557 Phase 2 Clinical Ionis Pharmaceuticals Inc Hypertriglyceridemia; Homozygous familial hypercholesterolemia; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Hyperlipoproteinemia Type I; Hyperlipoproteinemias; Dyslipidemias; Cardiovascular Diseases; Hyperlipoproteinemia Type II; Hyperlipidemias Details
Solbinsiran LY-3561774; DCR-CM-1; DCR-CM1 Phase 2 Clinical Dicerna Pharmaceuticals Inc Metabolic Diseases; Hyperlipoproteinemias; Dyslipidemias; Cardiovascular Diseases; Lipid Metabolism Disorders Details
LY-3475766 LY-3475766 Phase 1 Clinical Eli Lilly And Company Dyslipidemias Details
JS-401 JS-401 Phase 1 Clinical Shanghai Junshi Biological Engineering Co Ltd Hyperlipidemias Details
VERVE-201 VERVE-201 Phase 1 Clinical Broad Institute, Harvard University Homozygous familial hypercholesterolemia; Atherosclerosis; Hypercholesterolemia Details
NN-6491 NN6491; NN-6491 Phase 1 Clinical Novo Nordisk A/S Cardiovascular Diseases Details
NNC0491-6075 NNC0491-6075; NNC04916075 Phase 1 Clinical Novo Nordisk A/S Dyslipidemias Details
RP-912 RP-912; RP912 Phase 1 Clinical Runjia (Shanghai) Pharmaceutical Technology Co Ltd Metabolic Diseases Details
AZD-1705 AZD1705; AZD-1705 Phase 1 Clinical Parexel, Astrazeneca Plc Cardiovascular Diseases Details

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