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Your Position: Home > SMAC

SMAC

Brief Information

Name:Diablo homolog, mitochondrial
Target Synonym:Direct IAP-binding protein with low pI,Second mitochondria-derived activator of caspase,Smac,Diablo IAP-Binding Mitochondrial Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
DIO-H5129 Human Human SMAC / Diablo Protein, His Tag
DIO-H5129-structure
DIO-H5129-sds
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Synonym Name

DIABLO,SMAC

Background

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BI-891065 BI-891065 Phase 1 Clinical Boehringer Ingelheim Gmbh Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details

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