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SMAC

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Cat. No. Species Product Description Structure Purity Feature
DIO-H5129 Human Human SMAC / Diablo Protein, His Tag
DIO-H5129-structure
DIO-H5129-sds

SMAC Molecule Synonym Name

DIABLO,SMAC

SMAC Molecule Background

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

SMAC References

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