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Dkk-1

Dkk-1 Molecule Information

Name:Dickkopf-related protein 1
Target Synonym:hDkk-1;Dickkopf-1;DKK1;SK;Dkk-1;Dickkopf-related protein 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase ?

Dkk-1 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
DK1-H82F5 Human Biotinylated Human Dkk-1 Protein, Fc,Avitag™
DK1-H82F5-structure
DK1-H82F5-sds
DK1-H82F5-elisa_1
DK1-H5258 Human Human Dkk-1 Protein, Fc Tag
DK1-H5258-structure
DK1-H5258-sds
DK1-M52H6 Mouse Mouse Dkk-1 Protein, His Tag
DK1-M52H6-structure
DK1-M52H6-sds
DK1-M52H6-elisa_1
DK1-H5286 Human Human Dkk-1 Protein, Strep Tag
DK1-H5286-structure
DK1-H5286-sds
DK1-H5286-elisa_1
DK1-H5221 Human Human Dkk-1 Protein, His Tag
DK1-H5221-structure
DK1-H5221-sds
DK1-H5221-elisa_1

Dkk-1 Molecule Synonym Name

DKK1,SK

Dkk-1 Molecule Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via ¦Â-catenin mediated Pdgfr¦Á and E-cadherin expression.

Dkk-1 References

Dkk-1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
DKN-01 DKN-01; LY-2812176 Phase Ⅱ Lilly, Leap Therapeutics Gastric cancer, Prostate cancer, Endometrial cancer, oesophageal cancer, Liver cancer, Ovarian cancer Details
Mab-B3 Mab-B3 Phase Ⅰ Lilly Bone disorders Details
RN-564 PF-04840082; PF-4840082; RN-564 Phase Ⅰ Pfizer Osteoporosis Details
Recombinant human R-spondin 1 NU-206; R-Spondin-1; RSpo-1 Phase Ⅰ ARCA biopharma, Kyowa Hakko Kirin wound, Bone disorders, Mucositis, Inflammatory bowel disease Details
BHQ-880 BHQ-880; MOR-4910 Phase Ⅱ MorphoSys, Novartis Solid tumours, Multiple myeloma (MM) Details

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