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Dkk-1

Brief Information

Name:Dickkopf-related protein 1
Target Synonym:Dickkopf-Like Protein 1,Dickkopf 1 Homolog,Dickkopf-1 Like,Dickkopf-1,Dkk-1,UNQ492/PRO1008,Dickkopf-related protein 1,hDkk-1,SK,DKK1,Dickkopf WNT Signaling Pathway Inhibitor 1,Dickkopf 1 Homolog (Xenopus Laevis),Dickkopf (Xenopus Laevis) Homolog 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

DK1-M52H6-ELISA
Mouse Dkk-1, His TagMouse Dkk-1, His Tag (Cat. No. DK1-M52H6) ELISA bioactivity

Immobilized Mouse Dkk-1, His Tag (Cat. No. DK1-M52H6) at 5 μg/mL (100 μL/well) can bind Human LRP-5, Mouse IgG2a Fc Tag (Cat. No. LR5-H5254) with a linear range of 0.01-0.313 μg/mL (QC tested).

DK1-H82F5-ELISA
Biotinylated Human Dkk-1, Fc,AvitagBiotinylated Human Dkk-1, Fc,Avitag (Cat. No. DK1-H82F5) ELISA bioactivity

Immobilized Biotinylated Human Dkk-1, Fc,Avitag (Cat. No. DK1-H82F5) at 5 μg/mL (100 μL/well) on Streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Human LRP-5, Mouse IgG2a Fc Tag (Cat. No. LR5-H5254) with a linear range of 0.5-16 ng/mL (QC tested).

Synonym Name

DKK1,SK

Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via ¦Â-catenin mediated Pdgfr¦Á and E-cadherin expression.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BHQ-880 BHQ-880; MOR-4910 Phase 2 Clinical Novartis Pharma Ag, Morphosys Renal Insufficiency; Smoldering Multiple Myeloma; Multiple Myeloma Details
DKN-01 LY-2812176; DKN-01 Phase 2 Clinical Eli Lilly And Company Liver Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Multiple Myeloma; Prostatic Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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