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DNAM-1

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Part of Bioactivity data

DN1-H82F9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows Biotinylated Human DNAM-1, Fc,Avitag (Cat. No. DN1-H82F9) can bind to 293T cell overexpressing human CD155. The concentration of DNAM-1 is 0.03 μg/mL (Routinely tested).

DN1-H5257-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that recombinant Human DNAM-1 Protein, Fc Tag (Cat. No. DN1-H5257) can bind to 293T cell overexpressing human CD155. The concentration of DNAM-1 used is 0.03 μg/ml (Routinely tested).

DN1-M52H5-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human CD155, Fc Tag (Cat. No. CD5-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Mouse DNAM-1, His Tag (Cat. No. DN1-M52H5) with an affinity constant of 0.816 μM as determined in a SPR assay (Biacore 8K) (QC tested).

DN1-C52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human CD155, Fc Tag (Cat. No. CD5-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Canine DNAM-1, His Tag (Cat. No. DN1-C52H4) with an affinity constant of 31.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

DNAM1,CD226,PTA1

Background

DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.

Clinical and Translational Updates

Related Molecule

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