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DNAM-1

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Cat. No. Species Product Description Structure Purity Feature
DN1-C52H9 Cynomolgus Cynomolgus DNAM-1 / CD226 Protein, His Tag
DN1-C52H9-structure
DN1-C52H9-sds
DN1-C52H9-elisa_1
DN1-H82F9 Human Biotinylated Human DNAM-1 / CD226 Protein, Fc,Avitag™
DN1-H82F9-structure
DN1-H82F9-sds
DN1-H82F9-elisa_1
DN1-H5257 Human Human DNAM-1 / CD226 Protein, Fc Tag
DN1-H5257-structure
DN1-H5257-sds
DN1-H5257-elisa_1
DN1-H52H6 Human Human DNAM-1 / CD226 Protein, His Tag
DN1-H52H6-structure
DN1-H52H6-sds
DN1-H52H6-elisa_1

DNAM-1 Part of Bioactivity data

DN1-H82F9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows Biotinylated Human DNAM-1, Fc,Avitag (Cat. No. DN1-H82F9) can bind to 293T cell overexpressing human CD155. The concentration of DNAM-1 is 0.03 μg/mL (Routinely tested).

DN1-H5257-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that recombinant Human DNAM-1 Protein, Fc Tag (Cat. No. DN1-H5257) can bind to 293T cell overexpressing human CD155. The concentration of DNAM-1 used is 0.03 μg/ml (Routinely tested).

DN1-C52H9-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD155, Fc Tag (Cat. No. CD5-H5251) on Protein A Biosensor, can bind Cynomolgus DNAM-1, His Tag (Cat. No. DN1-C52H9) with an affinity constant of 0.88 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

DN1-H5257-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human DNAM-1, Fc Tag (Cat. No. DN1-H5257) on Protein A Biosensor, can bind Human CD155, His Tag (Cat. No. CD5-H5223) with an affinity constant of 1.1 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

DNAM-1 Molecule Synonym Name

DNAM1,CD226,PTA1

DNAM-1 Molecule Background

DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.

DNAM-1 References

DNAM-1 Related Molecule

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