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Your Position: Home > E-Cadherin

E-Cadherin

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Cat. No. Species Product Description Structure Purity Feature
ECD-H5250 Human Human E-Cadherin / Cadherin-1 Protein, Fc Tag
ECD-H5250-structure
ECD-H5250-sds

Synonym Name

Cadherin-1,CDH1,CD324,E-cadherin,Arc-1,ECAD,LCAM,UVO

Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

Clinical and Translational Updates

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