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Ephrin-A4 Molecule Information

Target Synonym:LERK-4;EPH-related receptor tyrosine kinase ligand 4;EPLG4;LERK4;EFNA4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
EA4-H5229 Human Human Ephrin-A4 / EFNA4 Protein, His Tag
EA4-H5250 Human Human Ephrin-A4 / EFNA4 Protein, Fc Tag

Ephrin-A4 Part of Bioactivity data

Human Ephrin-A4, Fc TagHuman Ephrin-A4, Fc Tag (Cat. No. EA4-H5250) ELISA bioactivity

Immobilized Human EphA4, His Tag (Cat. No. EP4-H52H8) at 5 μg/mL (100 μL/well) can bind Human Ephrin-A4, Fc Tag (Cat. No. EA4-H5250) with a linear range of 0.6-5 ng/mL (QC tested).

Ephrin-A4 Molecule Synonym Name


Ephrin-A4 Molecule Background

Ephrin-A4 (EFNA4) is also known as EPH-related receptor tyrosine kinase ligand 4 (LERK4), EPLG4, which belongs to the ephrin family. EFNA4 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA4 is cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA4 may play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Ephrin-A4 References

Ephrin-A4 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PF-0667263 PF-06647263; PF-0667263; PF-6647263 Phase Ⅰ Pfizer Solid tumours Details

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