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PSMA

Brief Information

Name:Glutamate carboxypeptidase II
Target Synonym:EC:3.4.17.21,GIG27,Glutamate carboxypeptidase II,NAALADase I,FOLH,Cell growth-inhibiting gene 27 protein,PSM,N-acetylated-alpha-linked acidic dipeptidase I,GCPII,Folylpoly-gamma-glutamate carboxypeptidase,Folate hydrolase 1,FOLH1,Pteroylpoly-Gamma-Glutama
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Approved

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Part of Bioactivity data

PSA-HP2Q3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-PSMA CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human PSMA, His Tag (Cat. No. PSA-HP2Q3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

PSA-H5264-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis of Human PSMA, Fc Tag binding to PSMA-CAR-293 cells transfected with anti-PSMA-scFv 2X105 of PSMA-CAR-293 cells transfected with anti-PSMA-scFv were stained with 100μl of 1μg/mL of Human PSMA, Fc Tag (Cat. No. PSA-H5264) and negative control protein respectively, washed and then followed by PE anti-human IgG Fc antibody and analyzed with FACS (Routinely tested).

PSA-H5264-ELISA
Human PSMA, Fc TagHuman PSMA, Fc Tag (Cat. No. PSA-H5264) ELISA bioactivity

Immobilized Human PSMA, Fc Tag (Cat. No. PSA-H5264) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human PSMA Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

PSA-R5245-MALS-HPLC
Rat PSMA, His Tag (Cat. No. ) MALS images

The purity of Rat PSMA, His Tag (Cat. No. PSA-R5245) was more than 90% and the molecular weight of this protein is around 170-208 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to hydrolyze the substrate N-acetyl-L-Asp-L-Glu into N-acetyl-L-Asp and L-Glu. The L-Glu product is measured by fluorescence after its derivatization by ortho-phthaldialdehyde. The specific activity is >300 pmol/min/μg, as measured under the described conditions (QC tested).

Customer Reviews

Synonym Name

FOLH1,PSMA,GIG27,FOLH,NAALAD1,PSM,NAALADase I,GCPII,FGCP

Background

The biotinylated PSMA protein was conjugated to streptavidin magnetic beads. This pre-coupled magnetic bead product can capture the anti-PSMA antibody from various assay systems. The beads are in uniform size, narrow size distribution with large surface area and unique surface coating, which can help you get the best performance and highly reproducible results. This PSMA coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. This ready-to-use product could greatly save your time and hassle.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Capromab pendetide lndium-CYT-356; Indium-111-CYT-356; CYT-356; 111In CYT-356 Approved Eusa Pharma ProstaScint United States Prostatic Neoplasms Cytogen 1996-10-28 Prostatic Neoplasms Details
Piflufolastat F 18 Approved Johns Hopkins University Pylarify United States Prostatic Neoplasms Progenics Pharmaceuticals Inc 2021-05-26 Carcinoma, Renal Cell; Prostatic Neoplasms Details
Gallium GA-68 PSMA-11 Ga-68-PSMA-11; Ga-68-PSMA Approved Radiomedix Gallium Ga 68 Psma-11 United States Prostatic Neoplasms University Of California, San Francisco Foundation 2020-12-01 Prostatic Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-PSMA CAR T-cell therapy (TNK Therapeutics) Phase 1 Clinical Sorrento Therapeutics Neoplasms Details
Gallium-68 PSMA-617 PSMA-617-[68Ga]; 225 Ac-PSMA-617; 68Ga-PSMA-617; 68Ga-DKFZ-617; 68Ga-DOTA-PSMA-DKFZ -617; Gallium-68-PSMA-617; 68Ga-DKFZ-PSMA -617 Clinical Deutsches Krebsforschungszentrum, University Of Heidelberg Prostatic Neoplasms Details
P28z-CAR P28z-CAR Phase 1 Clinical Memorial Sloan Kettering Cancer Center, United States Department Of Defense Prostatic Neoplasms Details
CC-1 CC-1 Phase 1 Clinical The University Of Tubingen, Deutsches Krebsforschungszentrum, Dkfz Prostatic Neoplasms Details
CART-PSMA-TGFbRDN (University of Pennsylvania) Phase 1 Clinical University Of Pennsylvania Prostatic Neoplasms Details
INO-5401 INO5401; INO-5401 Phase 2 Clinical Inovio Glioblastoma; Carcinoma, Transitional Cell Details
Autologous T-cell therapy (anti-PSMA-CD3), Roger Williams Medical Center Phase 1 Clinical Roger Williams Medical Center Prostatic Neoplasms Details
[131I]MIP-1095 1095; [131I]MIP-1095; [131I]MIP-1466 Phase 2 Clinical Progenics Pharmaceuticals Inc Prostatic Neoplasms Details
89Zr-DFO-huJ591 Zr89-J591; 89Zr-DFO-J591; 89Zr-DFO-huJ591 Phase 2 Clinical Memorial Sloan Kettering Cancer Center Prostatic Neoplasms Details
Df-IA2BM-Zr-89 IAB2M; 89Zr-Df-IAB2M; Df-IA2BM-Zr-89; 64Cu-NODAGA-PSMA-Mb Phase 2 Clinical Imaginab Prostatic Neoplasms; Glioma Details
INO-5150 INO-5150 Phase 1 Clinical Inovio Prostatic Neoplasms Details
4SCAR-PSMA T cell therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
68Ga-PSMA-R2 (Advanced Accelerator Applications SA) Clinical Advanced Accelerator Applications Prostatic Neoplasms Details
177Lu-PSMA-R2 177Lu-PSMA-R2; 177Lu-PSMA-SR6 Phase 2 Clinical Advanced Accelerator Applications Prostatic Neoplasms Details
Fluorine-18-CTT-1057 CTT-1057; 18F-CTT1057; CTT-1057-18F; CTT-1057-F-18 Phase 3 Clinical Washington University, Cancer Targeted Technology Carcinoma, Renal Cell; Prostatic Neoplasms Details
HPN-424 HPN-424 Phase 2 Clinical Harpoon Therapeutics Prostatic Neoplasms Details
67Cu-SAR-bisPSMA (Clarity Pharmaceuticals) Phase 2 Clinical Prostatic Neoplasms, Castration-Resistant Details
64Cu-SAR-bisPSMA (Clarity Pharmaceuticals) Phase 2 Clinical Prostatic Neoplasms, Castration-Resistant Details
PSMA-CART cell therapy (Shanghai Bioray Laboratory) Phase 1 Clinical Bioray Laboraytories Inc Prostatic Neoplasms Details
ATL-101 (ATLAB) J-591; MLN-591; huJ-591; muJ-591; 90Y-J591; MLN-591RL; 177Lu-J591; Lu-177-J591 Phase 2 Clinical Cornell University Prostatic Neoplasms Details
ARX-517 ARX-517 Phase 1 Clinical Ambrx Inc Solid tumours; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
Acapatamab AMG-160 Phase 1 Clinical Amgen Inc Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details
TNB-585 TNB-585 Phase 1 Clinical Teneobio Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details

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