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Your Position: Home > Furin

Furin

Brief Information

Name:Furin
Target Synonym:Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FUN-H52H3 Human Human Furin / PCSK3 Protein, His Tag
FUN-H52H3-structure
FUN-H52H3-sds

Synonym Name

FURIN,FUR,PACE,PCSK3,SPC1

Background

Furin is also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy (Gradalis/Mary Crowley) IND-14205 Phase 3 Clinical Gradalis Ovarian Neoplasms; Liver Neoplasms; Colonic Neoplasms; Breast Neoplasms; Sarcoma, Ewing; Peritoneal Neoplasms; Genital Neoplasms, Female; Uterine Neoplasms; Fallopian Tube Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details

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