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Your Position: Home > Frizzled-2

Frizzled-2

Brief Information

Name:Frizzled-2
Target Synonym:Frizzled Class Receptor 2,Frizzled 2, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 2,FzE2,Fz-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FZ2-H5255 Human Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag
FZ2-H5255-structure
FZ2-H5255-sds
FZ2-H5251 Human Human Frizzled-2 / FZD2 Protein, Fc Tag
FZ2-H5251-structure
FZ2-H5251-sds
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Synonym Name

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

Background

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Vantictumab OMP-18R5; anti-Fzd7 Phase 1 Clinical Oncomed Pharmaceuticals Inc, Bayer AG Solid tumours; Pancreatic Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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