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GPA33 Molecule Information

Name:Cell surface A33 antigen
Target Synonym:Glycoprotein A33;GPA33
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
GP3-H8224 Human Biotinylated Human GPA33 Protein, His Tag, ultra sensitivity (primary amine labeling)
GP3-M5225 Mouse Mouse GPA33 / A33 Protein, His Tag
GP3-H5224 Human Human GPA33 / A33 Protein, His Tag

GPA33 Molecule Synonym Name


GPA33 Molecule Background

Glycoprotein A33 (GPA33) is also known as Cell surface A33 antigen, is a single-pass type I membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily, which contains. GPA33 may play a role in cell-cell recognition and signaling.

GPA33 References

GPA33 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anticancer monoclonal antibody A33 (Ludwig Institute for Cancer Research) 124I-huA33; 131I-huA33; 131I-huAb A33 Phase Ⅰ Ludwig Institute for Cancer Research Colorectal cancer Details
MGD-007 MGD-007; gpA33-xCD3 Phase Ⅰ MacroGenics, Servier Colorectal cancer Details
A33-radionuclides CDP-833; hA33-90Y Phase Ⅰ Celltech Colorectal cancer Details
KRN-330 KRN-330 Phase Ⅱ Kyowa Hakko Kirin Colorectal cancer Details

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