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Your Position: Home > GPA33

GPA33

Brief Information

Name:Cell surface A33 antigen
Target Synonym:Cell surface A33 antigen,Glycoprotein A33,GPA33,Glycoprotein A33 (Transmembrane),Transmembrane Glycoprotein A33,A33
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

GP3-H5253-ELISA
Human GPA33, Fc TagHuman GPA33, Fc Tag (Cat. No. GP3-H5253) ELISA bioactivity

Immobilized Human GPA33, Fc Tag (Cat. No. GP3-H5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GPA33 Antibody, Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

GP3-C5253-MALS-HPLC
Cynomolgus GPA33, Fc Tag (Cat. No. ) MALS images

The purity of Cynomolgus GPA33, Fc Tag (Cat. No. GP3-C5253) was more than 90% and the molecular weight of this protein is around 108-132 kDa verified by SEC-MALS.

Bioactivity-ELISA
Cynomolgus GPA33, Fc TagCynomolgus GPA33, Fc Tag (Cat. No. GP3-C5253) ELISA bioactivity

Immobilized Cynomolgus GPA33, Fc Tag (Cat. No. GP3-C5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GPA33 Antibody, Human IgG1 with a linear range of 1-5 ng/mL (QC tested).

Synonym Name

GPA33,A33

Background

Glycoprotein A33 (GPA33) is also known as Cell surface A33 antigen, is a single-pass type I  membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily, which contains. GPA33 may play a role in cell-cell recognition and signaling.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MGD-007 MGD-007; gpA33-xCD3 Phase 1 Clinical Macrogenics Colorectal Neoplasms Details

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