Osteoactivin
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Osteoactivin Molecule Synonym Name
GPNMB,HGFIN,NMB,Osteoactivin
Osteoactivin Molecule Background
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Osteoactivin References
- Weterman MA., et al., 1995, International Journal of Cancer 60 (1): 73¨C81.
- Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334¨C51.
- Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26¨C37.
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