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Your Position: Home > HSP90AA1

HSP90AA1

Brief Information

Name:Heat shock protein HSP 90-alpha
Target Synonym:Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1,Heat Shock 90kDa Protein 1, Alpha,Heat Shock 90kD Protein 1, Alpha,HSP 86,HSP90A,HSPC1,Heat Shock Protein 90kDa Alpha Family Class A Member 1,Epididymis Secretory Sperm Binding Protein Li 65p,Epididymis Luminal Secretory Protein 52,Heat Shock 90kD Protein 1, Alpha-Like 4,Heat Shock 90kD Protein, Alpha-Like 4,HEL-S-65p,FLJ31884,HSPCAL1,HSPCAL4,HSP89A,HSP90N,Hsp103,Hsp89,Hsp90,EL52,HSPN,LAP2,Heat shock protein HSP 90-alpha,HSP86,LPS-asso
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
HS1-H513x Human Human HSP90AA1 / HSP86 Protein, GST Tag
HS1-H513x-structure
HS1-H513x-sds
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Synonym Name

HSP90AA1,HSP90A,HSP 86,HSP86,HSPC1,HSPCA,EL52,HSP89A,HSP90N,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2

Background

Heat shock protein HSP 90-alpha (HSP90AA1 or HSP90A) is also known as Heat shock 86 kDa (HSP 86 or HSP86), Renal carcinoma antigen NY-REN-38, HSPC1, HSPCA, EL52, HSP89A, HSP90N, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2, which belongs to the heat shock protein 90 family. HSP90AA1 undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. HSP90AA1 interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pimitespib TAS-116 Approved Taiho Pharmaceutical Co Ltd, Otsuka Pharmaceutical Co Ltd Jeselhy, ジェセリ Japan Gastrointestinal Stromal Tumors Taiho Pharmaceutical Co Ltd 2022-08-01 Solid tumours; Biliary Tract Neoplasms; Head and Neck Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Sarcoma, Alveolar Soft Part; Carcinoma, Non-Small-Cell Lung Details

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