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Your Position: Home > ICAM-1


Brief Information

Name:Intercellular adhesion molecule-1
Target Synonym:Intercellular Adhesion Molecule 1,Cell Surface Glycoprotein P3.58,Major group rhinovirus receptor,Human Rhinovirus Receptor,CD54 Antigen,P3.58,CD54,BB2,Intercellular Adhesion Molecule-1,ICAM1,ICAM-1,Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor,Epididymis Secretory Sperm Binding Protein
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Part of Bioactivity data


Immobilized Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT2-H53W3) at 10 μg/mL (100 μL/well) can bind Human ICAM-1, Fc Tag (Cat. No. IC1-H5250) with a linear range of 0.4-6 ng/mL (QC tested).

ICAM-1 MALS images

The purity of Biotinylated Human ICAM-1, His,Avitag (Cat. No. IC1-H82E8) is more than 85% and the molecular weight of this protein is around 65-80kDa verified by SEC-MALS.

Synonym Name



Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tocopherol acetate DSE-9912 Approved National Institute Of Diabetes And Digestive And Kidney Diseases Ephynal, Aquasol E Japan Vitamin E Deficiency; Atherosclerosis; Venous Thromboembolism; Thrombosis; Intermittent Claudication; Diabetic Retinopathy Eisai Co Ltd 1951-09-01 Atherosclerosis; Venous Thromboembolism; Intermittent Claudication; Metabolic Dysfunction-Associated Steatotic Liver Disease; Vitamin E Deficiency; Thrombosis; Diabetic Retinopathy Details
Ascorbic Acid/Biotin/Cholecalciferol/Cyanocobalamin/Dexpanthenol/Folic acid/Niacinamide/Pyridoxine/Riboflavin/Thiamine/Tocopherol Acetate/Vitamin A/Vitamin K Approved Sandoz Canada Inc Infuvite Pediatric United States Avitaminosis Sandoz Canada Inc 2001-02-21 Avitaminosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Gebasaxturev V-937; CVA-21 Phase 2 Clinical Viralytics Ltd Head and Neck Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Neoplasm Metastasis; Melanoma Details
AIC-100 AIC-100 Phase 1 Clinical Affyimmune Therapeutics Inc Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms Details

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