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ICAM-1

ICAM-1 Molecule Information

Name:Intercellular adhesion molecule-1
Target Synonym:Intercellular Adhesion Molecule 1,Cell Surface Glycoprotein P3.58,Human Rhinovirus Receptor,CD54 Antigen,P3.58,CD54,BB2,Intercellular Adhesion Molecule-1,Epididymis Secretory Sperm Binding Protein,Major group rhinovirus receptor,ICAM1,ICAM-1,Intercellular
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

ICAM-1 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IC1-H52H5 Human Human ICAM-1 / CD54 Protein, His Tag
IC1-H52H5-structure
IC1-H52H5-sds
IC1-H5250 Human Human ICAM-1 / CD54 Protein, Fc Tag
IC1-H5250-structure
IC1-H5250-sds
IC1-H5250-elisa_1

ICAM-1 Part of Bioactivity data

IC1-H5250-ELISA
Human ICAM-1, Fc TagHuman ICAM-1, Fc Tag (Cat. No. IC1-H5250) ELISA bioactivity

Immobilized Human ITGALB2, His tag at 5 μg/mL (100 μL/well) can bind Human ICAM-1, Fc Tag (Cat. No. IC1-H5250) with a linear range of 0.082-1.28 μg/mL (Routinely tested).

ICAM-1 Molecule Synonym Name

ICAM1,BB2,CD54,P3.58

ICAM-1 Molecule Background

Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

ICAM-1 References

ICAM-1 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tocopherol acetate DSE-9912 Approved Ephynal, Aquasol E N; Venous Thromboembolism; Atherosclerosis; Intermittent Claudication; Thrombosis; Diabetic Retinopathy Details

ICAM-1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bersanlimab BI-505 Phase 2 Clinical Bioinvent International Smoldering Multiple Myeloma; Multiple Myeloma Details
AIC-100 AIC-100 Phase 1 Clinical Affyimmune Therapeutics Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms Details
Coxsackievirus A21 (Viralytics) V-937; CVA-21 Phase 2 Clinical Viralytics Head and Neck Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Melanoma; Neoplasm Metastasis Details

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