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Your Position: Home > IL-13 R alpha 1

IL-13 R alpha 1

Brief Information

Name:Interleukin-13 receptor subunit alpha-1
Target Synonym:IL-13 receptor subunit alpha-1,IL-13R subunit alpha-1,IL-13R-alpha-1,IL-13RA1,Cancer/testis antigen 19,CD213a1,Interleukin 13 Receptor Subunit Alpha 1,CD213a1 Antigen,Interleukin-13 Receptor Subunit Alpha-1,Interleukin 13 Receptor, Alpha 1,IL-13 Receptor Subunit Alpha-1,IL13 Receptor Alpha-1 Chain,Cancer/Testis Antigen 19,IL-13R Subunit Alpha-1,IL-13Ra,NR4,IL-13R-Alpha-1,CD213A1,IL13RA1,IL13RA
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL1-H82E8-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-13 R alpha 1 Protein, His,Avitag (Cat. No. IL1-H82E8) captured on Biotin CAP-Series S Sensor Chip can bind Human IL-13, His Tag (Cat. No. IL3-H52H4) with an affinity constant of 34.4 nM as determined in a SPR assay (Biacore 8K) (QC tested).

IL1-H82F6-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-13 R alpha 1, Fc,Avitag (Cat. No. IL1-H82F6) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-13, His Tag (Cat. No. IL3-H52H4) with an affinity constant of 45.6 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

IL13RA1,CD213A1,IL-13Ra,NR4,RP13-128O4.2,IL13Rα1

Background

Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Eblasakimab MK-6105; ASLAN-004; CSL-334 Phase 2 Clinical Csl Ltd, Merck Sharp & Dohme Corp Dermatitis, Atopic; Hypersensitivity Details

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