0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-17F

IL-17F

Brief Information

Name:Interleukin-17F
Target Synonym:Cytokine ML-1,Interleukin-17F,IL17F,Interleukin 17F,IL-17F,CANDF6,ML-1,ML1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

By Product Status:
By Product Category:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ILF-H5244 Human Human IL-17F Protein, His Tag
ILF-H5244-structure
ILF-H5244-sds
ILF-H5244-elisa_1
ILF-C5243 Cynomolgus Cynomolgus IL-17F Protein, His Tag
ILF-C5243-structure
ILF-C5243-sds
ILF-C5243-elisa_1
ILF-M5249 Mouse Mouse IL-17F Protein, His Tag
ILF-M5249-structure
ILF-M5249-sds
ILF-M5249-elisa_2
ILF-H4240 Human Human IL-17F (H161R) Protein, His Tag
ILF-H4240-structure
ILF-H4240-sds
ILF-H4240-elisa_1

Part of Bioactivity data

ILF-M5249-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Mouse IL-17F, His Tag (Cat. No. ILF-M5249) with an affinity constant of 2.99 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILF-H5244-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Human IL-17F, His Tag (Cat. No. ILF-H5244) with an affinity constant of 219 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-17F,IL24,ML-1,Interleukin-17F

Background

Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ALX-0761 M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Psoriasis Details
BAT-2306 Phase 1 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012 Phase 2 Clinical Livzon Pharmaceutical Group Inc, Beijing Xinkanghe Biomedical Technology Co Ltd Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details

This web search service is supported by Google Inc.

totop