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IL-18BP

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Cat. No. Species Product Description Structure Purity Feature
ILP-H5253 Human Human IL-18BP Protein, Fc Tag (MALS verified)
ILP-H5253-structure
ILP-H5253-sds
ILP-H5222 Human Human IL-18BP Protein, His Tag (MALS verified)
ILP-H5222-structure
ILP-H5222-sds

Part of Bioactivity data

ILP-H5222-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-18BP, His Tag (Cat. No. ILP-H5222) inhibits the IL-18-induced IFN-gamma secretion by KG‑1 cells. The ED50 for this effect is 0.019-0.053 µg/mL in the presence of 30 ng/mL of Recombinant Human IL‑18 (Routinely tested).

ILP-H5253-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-18BP, Fc Tag (Cat. No. ILP-H5253) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-18, Tag Free (Cat. No. IL8-H5113) with an affinity constant of 1.71 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILP-H5253-MALS-HPLC
Human IL-18BP, Fc Tag (Cat. No. ) MALS images

The purity of Human IL-18BP, Fc Tag(Cat. No. ILP-H5253) is more than 85% and the molecular weight of this protein is around 115-135 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-18BP, Fc Tag (Cat. No. ILP-H5253) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-18, Tag Free (Cat. No. IL8-H5113) with an affinity constant of 1.71 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

IL18BP,IL18BPa,Tadekinig-alfa

Background

Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

Clinical and Translational Updates

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