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BACE-1

Brief Information

Name:Beta-secretase 1
Target Synonym:EC:3.4.23.46,EC 3.4.23,Beta-site amyloid precursor protein cleaving enzyme 1,KIAA1149,Asp 2,ASP2,Aspartyl protease 2,BACE,BACE1,Beta-Secretase 1,Membrane-Associated Aspartic Protease 2,Beta-Site APP-Cleaving Enzyme,Memapsin-2,Transmembrane Aspartic Protei
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

BA1-H5213-MALS-HPLC
Human BACE-1, Tag Free (Cat. No. ) MALS images

The purity of Human BACE-1, Tag Free (Cat. No. BA1-H5213) was more than 90% and the molecular weight of this protein is around 55-65 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >3.5 pmol/min/µg, as measured under the described conditions (QC tested).

BA1-H5220-MALS-HPLC
Human BACE-1, His Tag (Cat. No. ) MALS images

The purity of Human BACE-1, His Tag (Cat. No. BA1-H5220) was more than 95% and the molecular weight of this protein is around 55-65 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >2.5 pmol/min/µg, as measured under the described conditions (QC tested).

Synonym Name

BACE1,ASP2,BACE,FLJ90568,HSPC104,KIAA1149,Memapsin-2

Background

Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), ¦Â-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TAK-070 TAK-070 Phase 1 Clinical Takeda Alzheimer Disease Details
LY-3202626 LY-3202626 Phase 2 Clinical Eli Lilly And Company Alzheimer Disease Details
Lanabecestat AZD-3293; LY-3314814 Phase 3 Clinical Astrazeneca Pharmaceutical Co Ltd Renal Insufficiency; Hepatic Insufficiency; Alzheimer Disease Details
Elenbecestat E-2609; [14C]E2609 Phase 3 Clinical Eisai Co Ltd Alzheimer Disease Details
Umibecestat AMG-520; CNP-520 Phase 3 Clinical Novartis Pharma Ag Alzheimer Disease Details

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