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IL-22 Molecule Information

Target Synonym:ILTIF ;IL22;ZCYTO18;IL-10-related T-cell-derived-inducible factor;Cytokine Zcyto18;IL-22;Interleukin-22;IL-TIF
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
IL2-H8247 Human Biotinylated Human IL-22 Protein, His,Avitag™
IL2-H524a Human Human IL-22 Protein, His Tag

IL-22 Part of Bioactivity data

Human IL-22, His TagHuman IL-22, His Tag (Cat. No. IL2-H524a) ELISA bioactivity

Immobilized Human IL-22, His Tag (Cat. No. IL2-H524a) at 5 μg/mL (100 μL/well) can bind Anti-Human IL-22 MAb with a linear range of 0.5-16 ng/mL (QC tested).

Biotinylated Human IL-22, His,Avitag™Biotinylated Human IL-22, His,Avitag™ (Cat. No. IL2-H8247) ELISA bioactivity

Immobilized Biotinylated Human IL-22, His,Avitag (Cat. No. IL2-H8247) at 1 μg/mL (100 μL/well)on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate. can bind Human IL-22 Antibody with a linear range of 0.1-4 ng/mL (QC tested).

IL-22 Molecule Synonym Name


IL-22 Molecule Background

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

IL-22 References

IL-22 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Fezakinumab ILV-094; PF-5212367 Phase Ⅱ Pfizer Rheumatoid arthritis (RA) Details
ILV-095 ILV-095; PF-05212368; PF-5212368; WAY-264095,ILV095; PF05212368; PF5212368; WAY264095,ILV 095; PF 05212368; PF 5212368; WAY 264095 Phase Ⅰ Wyeth, Pfizer Psoriasis Details
ARGX-112 ARGX-112; LEO-138559; LP-0145 Phase Ⅰ argenx, Leo Pharma Atopic dermatitis Details

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