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IL-2 R gamma

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Cat. No. Species Product Description Structure Purity Feature
ILG-H85E8 Human Biotinylated Human IL-2 R gamma / CD132 Protein, His,Avitag™ (SPR verified)
ILG-H5256 Human Human IL-2 R gamma / CD132 Protein, Fc Tag

IL-2 R gamma Molecule Synonym Name


IL-2 R gamma Molecule Background

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as ?, ? and ?, which are non-covalently associated are identified. The ? and ? chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the ? chain, along with the ? subunit. The ? chain of the IL-2R can bind to the ? chain before receptor interaction with IL-2. The ? chain alone has a very weak affinity for IL-2, but after the ligand is bound to the ?/? heterodimer, the ? chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

IL-2 R gamma References

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