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IL-2 R gamma

Brief Information

Name:Interleukin-2 receptor subunit gamma
Target Synonym:Severe Combined Immunodeficiency,Interleukin 2 Receptor Subunit Gamma,Interleukin-2 Receptor Subunit Gamma,Common Cytokine Receptor Gamma Chain,P64,IL2RG,SCIDX,CD132 Antigen,GammaC,IL-2 Receptor Subunit Gamma,Cytokine Receptor Common Subunit Gamma,Interle
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

ILG-H85E8-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-2 R gamma, His,Avitag (Cat. No. ILG-H85E8) inhibits the IL-2-dependent proliferation of Mo7e cells. The EC50 for this effect is 4.08-5.90 µg/mL in the presence of 10 µg/mL of human IL-2 R beta and 50 ng/mL of human IL-2 (Routinely tested).

ILG-H85E8-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-2 R gamma, His,Avitag (Cat. No. ILG-H85E8) immobilized on SA Chip can bind Human IL-2, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 105 μM as determined in a SPR assay (Biacore T200) (QC tested).

ILA-M52H3-MALS-HPLC
Mouse IL-2 R gamma, His Tag (Cat. No. ) MALS images

The purity of Mouse IL-2 R gamma, His Tag (Cat. No. ILA-M52H3) was more than 85% and the molecular weight of this protein is around 45-55 kDa verified by SEC-MALS.

  • Background
    IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC

Background

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TYF-IL-2Rg gene-modified autologous stem cells (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute X-Linked Combined Immunodeficiency Diseases Details
THOR-707 THOR-707; SAR-444245 Phase 2 Clinical Synthorx Solid tumours; Skin Neoplasms; Mesothelioma; Carcinoma, Squamous Cell; Melanoma; Carcinoma, Non-Small-Cell Lung Details

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