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IL-2 R gamma

IL-2 R gamma Part of Bioactivity data

ILG-H85E8-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-2 R gamma, His,Avitag (Cat. No. ILG-H85E8) inhibits the IL-2-dependent proliferation of Mo7e cells. The EC50 for this effect is 4.08-5.90 µg/mL in the presence of 10 µg/mL of human IL-2 R beta and 50 ng/mL of human IL-2 (Routinely tested).

ILG-H85E8-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-2 R gamma, His,Avitag (Cat. No. ILG-H85E8) immobilized on SA Chip can bind Human IL-2, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 105 μM as determined in a SPR assay (Biacore T200) (QC tested).

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Cat. No. Species Product Description Structure Purity Feature
ILG-H85E8 Human Biotinylated Human IL-2 R gamma / CD132 Protein, His,Avitag™ (SPR verified)
ILG-H85E8-structure
ILG-H85E8-sds
ILG-H85E8-elisa_2
ILG-H5256 Human Human IL-2 R gamma / CD132 Protein, Fc Tag
ILG-H5256-structure
ILG-H5256-sds

IL-2 R gamma Molecule Synonym Name

IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC

IL-2 R gamma Molecule Background

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as ?, ? and ?, which are non-covalently associated are identified. The ? and ? chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the ? chain, along with the ? subunit. The ? chain of the IL-2R can bind to the ? chain before receptor interaction with IL-2. The ? chain alone has a very weak affinity for IL-2, but after the ligand is bound to the ?/? heterodimer, the ? chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

IL-2 R gamma References

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