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IL-2 R gamma

Brief Information

Name:Interleukin-2 receptor subunit gamma
Target Synonym:Common Cytokine Receptor Gamma Chain,IL-2R Subunit Gamma,IL2RG,SCIDX,CD132,CIDX,IL-2RG,IMD4,Nonfunctional Common Cytokine Receptor Gamma Chain,Combined Immunodeficiency, X-Linked,Interleukin 2 Receptor Subunit Gamma,Interleukin-2 Receptor Subunit Gamma,Severe Combined Immunodeficiency,Cytokine Receptor Common Subunit Gamma,CD132 Antigen,GammaC,Interleukin 2 Receptor, Gamma,IL-2 Receptor Subunit Gamma,SCIDX1,P64
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

ILG-H85E8-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-2 R gamma, His,Avitag (Cat. No. ILG-H85E8) inhibits the IL-2-dependent proliferation of Mo7e cells. The EC50 for this effect is 4.08-5.90 µg/mL in the presence of 10 µg/mL of human IL-2 R beta and 50 ng/mL of human IL-2 (Routinely tested).

IL-2 R gamma MALS images

The purity of Biotinylated Mouse IL-2 R gamma Protein, His,Avitag (Cat. No. ILA-M82E3) is more than 85% and the molecular weight of this protein is around 40-55 kDa verified by SEC-MALS.

Cynomolgus IL-2 R gamma, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus IL-2 R gamma, His Tag (Cat. No. ILG-C52H9) is more than 85% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Synonym Name



IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Nanrilkefusp alfa SO-C101; RLI-15; CYP-0150; SOT-101 Phase 2 Clinical Microsatellite instability-high cancer; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Thymus Neoplasms; Urinary Bladder Neoplasms; Mesothelioma; Prostatic Neoplasms, Castration-Resistant; Thyroid Diseases; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Anus Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms Details
MB-107 IND-14570; MB-107 Phase 2 Clinical St Jude Children's Research Hospital, National Institute Of Allergy And Infectious Diseases (Niaid), National Heart, Lung And Blood Institute, National Institute of Health, Islamabad X-Linked Combined Immunodeficiency Diseases; Immunologic Deficiency Syndromes Details
GI-101 SIM-323; SIM323; GI-101 Phase 2 Clinical GI Innovation Inc Solid tumours; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Vaginal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Urinary Bladder Neoplasms; Sarcoma; Vulvar Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
THOR-707 THOR-707; SAR-444245 Phase 2 Clinical Synthorx Inc Oropharyngeal Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Esophageal adenocarcinoma; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Colorectal Neoplasms; Intestinal Neoplasms; Mesothelioma; Skin Neoplasms; Lymphoma, Large B-Cell, Diffuse; Hodgkin Disease; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Head and Neck Neoplasms Details
REGN-7257 REGN-7257 Phase 2 Clinical Regeneron Pharmaceuticals Inc Anemia, Aplastic Details
IAP-0971 IAP-0971 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms; Urinary Bladder Neoplasms Details
TransCon IL-2 β/γ Phase 2 Clinical Ascendis Pharma A/S Head and Neck Neoplasms; Solid tumours; Ovarian Neoplasms; Neoplasm Metastasis Details
TYF-IL-2Rg gene-modified autologous stem cells (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute X-Linked Combined Immunodeficiency Diseases Details
Simlukafusp alfa FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP Phase 1 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma Details
BJ-001(Boji Biomedical Technology) BJ-001 Phase 1 Clinical Boji Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Communicable Diseases; Neoplasm Metastasis Details
NL-201 (Neoleukin Therapeutics) NL-201 Phase 1 Clinical Neoleukin Therapeutics Inc Solid tumours Details
Recombinant human interleukin 15(Beijing Kawin) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Solid tumours Details

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