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Your Position: Home > Bcl-x

Bcl-x

Brief Information

Name:Apoptosis regulator Bcl-X
Target Synonym:Bcl-2-like protein 1,Bcl2-L-1,BCL2L,Apoptosis regulator Bcl-X,BCL2L1,BCL2 Like 1,Protein Phosphatase 1, Regulatory Subunit 52,BCLX,BCL-XL/S,PPP1R52,Bcl-X,bcl-X Protein,Bcl-XL,Bcl-XS
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
BC1-H513a Human Human Bcl-x / BCL2L1 Protein, GST Tag
BC1-H513a-structure
BC1-H513a-sds
BC1-H5120 Human Human Bcl-x / BCL2L1 Protein, His Tag
BC1-H5120-structure
BC1-H5120-sds

Synonym Name

BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL/S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

Background

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
R-(-)-gossypol acetic acid AT-101; BL-193; TW-37 Phase 2 Clinical Jiangsu Yasheng Pharmaceutical Development Co Ltd, University Of Michigan, Ascenta Esophageal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Small Cell Lung Carcinoma; Glioblastoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Prostatic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung Details
UBX-1325 UBX-1325 Phase 2 Clinical Unity Biotechnology Inc Diabetic macular oedema; Macular Degeneration Details
DT-2216 DT-2216 Phase 1 Clinical Dialectic Therapeutics Inc, University Of Florida Hematologic Neoplasms; Solid tumours Details
LP-118 LP-118 Phase 1 Clinical Guangzhou Lupeng Pharmaceutical Co Ltd, Newave Pharmaceutical Inc Lymphoma, B-Cell; Solid tumours; Myelodysplastic Syndromes; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Lymphoma, Non-Hodgkin; Leukemia, Prolymphocytic, T-Cell; Leukemia, Myeloid, Acute; Myelodysplastic-Myeloproliferative Diseases Details
Pelcitoclax BM-1252; APG-1252 Phase 2 Clinical Jiangsu Yasheng Pharmaceutical Development Co Ltd Solid tumours; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lymphoma, Extranodal NK-T-Cell; Primary Myelofibrosis; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung Details
AZD-0466 AZD-0466 Phase 2 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Hematologic Neoplasms; Multiple Myeloma; Lymphoma; Lymphoma, Non-Hodgkin Details

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