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Your Position: Home > Kallikrein 3

Kallikrein 3

Brief Information

Name:Prostate-specific antigen
Target Synonym:EC 3.4.21,EC:3.4.21.77,P-30 antigen,Semenogelase,APS,Prostate-specific antigen,PSA,Kallikrein Related Peptidase 3,Gamma-Seminoprotein,KLK3,Kallikrein-3,Seminin,Kallikrein 3, (Prostate Specific Antigen),EC 3.4.21.77,KLK2A1,HK3
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

Synonym Name

KLK3,Kallikrein-3,APS,KLK2A1,PSA,Hk3,Seminin,Semenogelase

Background

Kallikrein-3 (KLK3) is also known as Prostate-specific antigen (PSA), APS, Gamma-seminoprotein (Seminin), P-30 antigen, Semenogelase, is a glycoprotein enzyme, is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. The preferential cleavage site of KLK3 is ¡°-Tyr-|-Xaa-¡°, the catalytic activity is inhibited by SERPINA5 and is strongly inhibited by Zn2+. KLK3 hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Clinical and Translational Updates

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