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Kininogen 1

Brief Information

Name:Kininogen-1
Target Synonym:KNG1,Alpha-2-Thiol Proteinase Inhibitor,Kallidin II,Fitzgerald Factor,HMWK,Kallidin I,Williams-Fitzgerald-Flaujeac Factor,Bradykinin,Kininogen 1,Kininogen-1,High Molecular Weight Kininogen,BK,Kininogen,KNG,BDK,Ile-Ser-Bradykinin
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

Synonym Name

KNG1,Kininogen-1,HMWK,BDK,KNG

Background

Kininogen-1 (KNG1) is also known as HMWK, BDK, KNG, is a secreted protein which contains three cystatin domains. KNG1 can be cleaved into the following six chains: Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Clinical and Translational Updates

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