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Your Position: Home > Lipocalin-2

Lipocalin-2

Brief Information

Name:Neutrophil gelatinase-associated lipocalin
Target Synonym:NGAL,25 kDa alpha-2-microglobulin-related subunit of MMP-9,Lipocalin-2,Oncogene 24p3,Siderocalin,NGALp25
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
LC2-C5223 Cynomolgus Cynomolgus Lipocalin-2 / NGAL Protein, His Tag (MALS verified)
LC2-C5223-structure
LC2-C5223-sds
LC2-H5222 Human Human Lipocalin-2 / NGAL Protein, His Tag
LC2-H5222-structure
LC2-H5222-sds
ACRO Quality

Part of Bioactivity data

LC2-C5223-ELISA
Lipocalin-2 MALS images

The purity of Cynomolgus Lipocalin-2, His Tag (Cat. No. LC2-C5223) is more than 85% and the molecular weight of this protein is around 23-33 kDa verified by SEC-MALS.

Synonym Name

NGAL,LCN2,Lipocalin-2,24p3,MSFI

Background

Lipocalin-2 (LCN2) is also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4)NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.

Clinical and Translational Updates

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