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LIF R

LIF R Molecule Information

Name:LIFR/GP130
Target Synonym:CD_antigen=CD118?Oncostatin-M receptor subunit alpha?CD_antigen=CD130?IL-6R-beta?gp130?Interleukin-6 signal transducer?Membrane glycoprotein 130?IL-6R subunit beta?Leukemia inhibitory factor receptor?Interleukin-6 receptor subunit beta?LIFR?LIF-R?LIF rece
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

LIF R Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
LIR-H4252 Human Human LIF R / CD118 Protein, Fc Tag
LIR-H4252-structure
LIR-H4252-sds
LIR-H4252-elisa_1

LIF R Molecule Synonym Name

LIFR,CD118,FLJ98106,FLJ99923,SJS2,STWS,SWS

LIF R Molecule Background

Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

LIF R References

LIF R Related Molecule

LIF

LIF R Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Cardiotrophin-1 (Digna Biotech/Biotecnol) CT-1 Phase Ⅱ Biotecnol SA, Digna Biotech, Genentech Cardiac reperfusion injury, Acute kidney injury, Ischaemia Details
Emfilermin AM-424 Phase Ⅱ Walter and Eliza Hall Institute of Medical Research, Merck Serono, Zenyth Neuromuscular disorders, Infertility Details

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