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Brief Information

Name:Leukocyte immunoglobulin-like receptor B1
Target Synonym:Leukocyte Immunoglobulin Like Receptor B1,LIR-1,MIR-7,ILT2,LIR1,Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble Isoform,PIR-B,Leukocyte immunoglobulin-like receptor 1,MIR7,PIRB,CD85j,Immunoglobulin-like transcript 2,Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 1,Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1,Monocyte/Macrophage Immunoglobulin-Like Receptor 7,CD85 Antigen-Like Family Member J,Myeloid Inhibitory Receptor 7,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data


Biotinylated Human HLA-G&B2M&Peptide (RIIPRHLQL) Complex Protein (Cat. No. HLM-H82E4) captured on Biotin CAP-Series S Sensor Chip can bind Human LILRB1 (23-431) Protein, His Tag (Cat. No. CDJ-H52H6) with an affinity constant of 6.31 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Biotinylated Human HLA-G&B2M&Peptide (RIIPRHLQL) Complex Protein (Cat. No. HLM-H82E4) captured on Biotin CAP-Series S Sensor Chip can bind Human LILRB1, His Tag (Cat. No. CDJ-H52H4) with an affinity constant of 10.8 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

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Synonym Name



CD85 antigen-like family member J (CD85J) is also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1 or LIR-1), Immunoglobulin-like transcript 2 (ILT-2), Monocyte/macrophage immunoglobulin-like receptor 7 (MIR7), which belongs to leukocyte immunoglobulin-like receptor (LIR) family. CD85J / LILRB1 Contains 4 Ig-like C2-type (immunoglobulin-like) domains. CD85J / LIR-1 is expressed predominantly on B-cells and monocytes.  CD85J is receptor for class I MHC antigens and recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles and is also receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. CD85J / LILRB1 interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. CD85J / LILRB1 inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NGM-707 NGM-707 Phase 2 Clinical Merck & Co, Ngm Biopharmaceuticals Inc Ovarian Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Glioblastoma; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma Details
BND-22 BND-22; SAR-444881 Phase 2 Clinical Biond Biologics Ltd, Sanofi Neoplasms Details
IOS-1002 ios-H2 Phase 1 Clinical ImmunOs Therapeutics AG Solid tumours; Hematologic Neoplasms Details
AGEN-1571 AGEN-1571 Phase 1 Clinical Agenus Inc Solid tumours; Neoplasms Details

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