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Your Position: Home > LILRB2

LILRB2

Brief Information

Name:Leukocyte immunoglobulin-like receptor subfamily B member 2
Target Synonym:Leukocyte immunoglobulin-like receptor 2,CD85 antigen-like family member D,Immunoglobulin-like transcript 4,ILT-4,Monocyte/macrophage immunoglobulin-like receptor 10,MIR-10,CD_antigen: CD85d,LILRB2,Leukocyte Immunoglobulin Like Receptor B2,Leucocyte Ig-Like Receptor B2,MIR10,Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2,Ig-Like Transcript 4,Myeloid Inhibitory Receptor 10,CD85d Antigen,ILT4,LIR2,CD85d,LIR-2,LIRB2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
LI2-C52H3 Cynomolgus Cynomolgus LILRB2 / CD85d / ILT4 Protein, His Tag
LI2-C52H3-structure
LI2-C52H3-sds
LI2-C82E3 Cynomolgus Biotinylated Cynomolgus LILRB2 / CD85d / ILT4 Protein, His,Avitag™
LI2-C82E3-structure
LI2-C82E3-sds
LI2-H82F5 Human Biotinylated Human LILRB2 / CD85d / ILT4 Protein, Fc,Avitag™ (MALS verified)
LI2-H82F5-structure
LI2-H82F5-sds
CDD-H5259 Human Human LILRB2 / CD85d / ILT4 Protein, Fc Tag (MALS verified)
CDD-H5259-structure
CDD-H5259-sds
LI2-H5220 Human Human LILRB2 / CD85d / ILT4 Protein, His Tag (MALS verified)
LI2-H5220-structure
LI2-H5220-sds

Part of Bioactivity data

LI2-H5220-ELISA
Human LILRB2, His TagHuman LILRB2, His Tag (Cat. No. LI2-H5220) ELISA bioactivity

Immobilized Human LILRB2, His Tag (Cat. No. LI2-H5220) at 1 μg/mL (100 μL/well) can bind Anti-LILRB2 Antibody, Human IgG1 with a linear range of 0.5-4 ng/mL (QC tested).

Protocol
LI2-H82F5-MALS-HPLC
Biotinylated Human LILRB2, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human LILRB2, Fc,Avitag (Cat. No. LI2-H82F5) is more than 90% and the molecular weight of this protein is around 165-201 kDa verified by SEC-MALS.

Report
  • Background
    Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

LILRB2,ILT4,LIR2,MIR10,CD85d

Background

Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

Related Molecule

ANGPTL7

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NGM-707 NGM-707 Merck & Co, Ngm Biopharmaceuticals Details
IO-108 IO-108 Phase 1 Clinical Immune-Onc Therapeutics Inc Solid tumours Details
JTX-8064 JTX-8064 Jounce Therapeutics Details
MK-4830 MK-4830 Phase 2 Clinical Merck Sharp & Dohme Corp Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; uterine serous carcinoma; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details

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