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Your Position: Home > LILRB2

LILRB2

Brief Information

Name:Leukocyte immunoglobulin-like receptor subfamily B member 2
Target Synonym:Myeloid Inhibitory Receptor 10,CD85d Antigen,ILT4,LIR2,CD85d,LIR-2,Leukocyte immunoglobulin-like receptor 2,CD85 antigen-like family member D,Immunoglobulin-like transcript 4,ILT-4,Monocyte/macrophage immunoglobulin-like receptor 10,MIR-10,CD_antigen: CD8
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
LI2-C52H3 Cynomolgus Cynomolgus LILRB2 / CD85d / ILT4 Protein, His Tag
LI2-C52H3-structure
LI2-C52H3-sds
LI2-C82E3 Cynomolgus Biotinylated Cynomolgus LILRB2 / CD85d / ILT4 Protein, His,Avitag™
LI2-C82E3-structure
LI2-C82E3-sds
LI2-H82F5 Human Biotinylated Human LILRB2 / CD85d / ILT4 Protein, Fc,Avitag™
LI2-H82F5-structure
LI2-H82F5-sds
CDD-H5259 Human Human LILRB2 / CD85d / ILT4 Protein, Fc tag
CDD-H5259-structure
CDD-H5259-sds
CDD-H5259-elisa_1
LI2-H5220 Human Human LILRB2 / CD85d / ILT4 Protein, His Tag
LI2-H5220-structure
LI2-H5220-sds
LI2-H5220-elisa_1

Part of Bioactivity data

LI2-H5220-ELISA
Human LILRB2, His TagHuman LILRB2, His Tag (Cat. No. LI2-H5220) ELISA bioactivity

Immobilized Human LILRB2, His Tag (Cat. No. LI2-H5220) at 1 μg/mL (100 μL/well) can bind Anti-LILRB2 Antibody, Human IgG1 with a linear range of 0.5-4 ng/mL (QC tested).

Protocol
CDD-H5259-ELISA
Human LILRB2, Fc TagHuman LILRB2, Fc Tag (Cat. No. CDD-H5259) ELISA bioactivity

Immobilized Human LILRB2, Fc Tag (Cat. No. CDD-H5259) at 1 μg/mL (100 μL/well) can bind Anti-LILRB2 Antibody, Human IgG1 with a linear range of 1-2 ng/mL (QC tested).

Protocol

Synonym Name

LILRB2,ILT4,LIR2,MIR10,CD85d

Background

Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

Related Molecule

ANGPTL7

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JTX-8064 JTX-8064 Phase 1 Clinical Jounce Therapeutics Neoplasms Details
NGM-707 Phase 2 Clinical Merck & Co, Ngm Biopharmaceuticals Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Glioblastoma; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
MK-4830 MK-4830 Phase 2 Clinical Merck Sharp & Dohme Corp Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung Details

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