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Brief Information

Name:Leukocyte immunoglobulin-like receptor subfamily B member 2
Target Synonym:Leukocyte immunoglobulin-like receptor 2,CD85 antigen-like family member D,Immunoglobulin-like transcript 4,ILT-4,Monocyte/macrophage immunoglobulin-like receptor 10,MIR-10,CD_antigen: CD85d,LILRB2,Leukocyte Immunoglobulin Like Receptor B2,Leucocyte Ig-Like Receptor B2,MIR10,Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2,Ig-Like Transcript 4,Myeloid Inhibitory Receptor 10,CD85d Antigen,ILT4,LIR2,CD85d,LIR-2,LIRB2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
LILRB2 mAb - 01 PCC Solid Tumor Solid tumor

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ACRO Quality

Part of Bioactivity data


Immobilized Anti-LILRB2 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human LILRB2 Protein, His,Avitag (Cat. No. LI2-H82E7) with a linear range of 0.3-20 ng/mL (QC tested).

LILRB2 MALS images

The purity of Human LILRB2, Fc Tag (Cat. No. LI2-H5253) is more than 95% and the molecular weight of this protein is around 160-190 kDa verified by SEC-MALS.

Synonym Name



Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Polzastobart JTX-8064 Phase 2 Clinical Jounce Therapeutics Inc Neoplasms Details
IO-108 IO-108 Phase 2 Clinical Yiming Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Liver Neoplasms Details
MK-4830 MK-4830 Phase 2 Clinical Agenus Inc Ovarian Neoplasms; Solid tumours; Esophageal Neoplasms; Carcinoma, Ovarian Epithelial; uterine serous carcinoma; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details
OR-502 OR502; OR-502 Phase 2 Clinical OncoResponse Inc Solid tumours; Ovarian Neoplasms; Neoplasms; Carcinoma, Squamous Cell; Neoplasm Metastasis Details
NGM-707 NGM-707 Phase 2 Clinical Merck & Co, Ngm Biopharmaceuticals Inc Ovarian Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Glioblastoma; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma Details
SPX-303 SPX-303 Phase 1 Clinical SparX Biopharmaceutical Corp Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck Details
BMS-986406 BMS-986406 Phase 1 Clinical Bristol-Myers Squibb Company Neoplasms Details
CDX-585 CDX-585 Phase 1 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd, Celldex Therapeutics Liver Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ES-009 ES-009 Phase 1 Clinical Elpiscience (Shanghai) Biopharma Ltd Solid tumours; Neoplasms Details

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