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Your Position: Home > LTA4H

LTA4H

LTA4H Molecule Information

Name:Leukotriene A-4 hydrolase
Target Synonym:LTA4;LTA4H;Leukotriene A-4 hydrolase;Leukotriene A(4) hydrolase;LTA-4 hydrolase

Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

LTA4H Molecule Synonym Name

LTA4H,LTA4

LTA4H Molecule Background

Leukotriene A4 hydrolase (LTA4H) is a protein which belongs to the peptidase M1 family, specifically those acting on ether bonds (ether hydrolases). LTA4H is bifunctional enzyme which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase. LTA4H participates in arachidonic acid metabolism. LTA4H is inhibited by bestatin and subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. LTA4H binds 1 zinc ion per subunit.

LTA4H References

LTA4H Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Ubenimex	NK-421; NSC-265489; 1580RB	Approved	Nippon Kayaku, Eiger BioPharmaceuticals	Ubenimex Tablets	cfda	Acute myeloid Leukemia (AML), Cancer chemotherapy		2014-11-17	Lymphoblastic leukaemia	Details

LTA4H Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
JNJ-40929837	JNJ-40929837	Phase Ⅱ	Johnson & Johnson	Asthma	Details
BI-691751	BI-691751	Phase Ⅰ	Boehringer Ingelheim	Atherosclerosis	Details
DG-051	DG-051,DG051	Phase Ⅱ	Amgen	Myocardial infarction (MI)	Details
JNJ-27265732		Preclinical	Johnson & Johnson	Atopic dermatitis, Inflammatory bowel disease, Asthma	Details
Acebilustat	CTX-4430; EP-501	Phase Ⅱ	Celtaxsys	Cystic fibrosis (CF)	Details