Name:Leukotriene A-4 hydrolase Target Synonym:Leukotriene A-4 hydrolase,LTA4,LTA-4 hydrolase,LTA4H,Leukotriene A4 Hydrolase,Testicular Secretory Protein Li 27,Leukotriene A(4) Hydrolase,EC 3.3.2.6,EC:3.3.2.6
Number of Launched Drugs:1 Number of Drugs in Clinical Trials:1 Lastest Research Phase:Approved
Synonym Name
LTA4H,LTA4
Background
Leukotriene A4 hydrolase (LTA4H) is a protein which belongs to the peptidase M1 family, specifically those acting on ether bonds (ether hydrolases). LTA4H is bifunctional enzyme which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase. LTA4H participates in arachidonic acid metabolism. LTA4H is inhibited by bestatin and subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. LTA4H binds 1 zinc ion per subunit.
A-Z
FLAG
Star Staining
ViruStop
Aneuro
ComboX
ActiveMax
GENPower
