Name:Leukotriene A-4 hydrolase Target Synonym:Leukotriene A-4 hydrolase,LTA4,LTA-4 hydrolase,LTA4H,Leukotriene A4 Hydrolase,Testicular Secretory Protein Li 27,Leukotriene A(4) Hydrolase,EC 18.104.22.168,EC:22.214.171.124
Number of Launched Drugs:1 Number of Drugs in Clinical Trials:1 Lastest Research Phase:Approved
LTA4H Molecule Synonym Name
LTA4H Molecule Background
Leukotriene A4 hydrolase (LTA4H) is a protein which belongs to the peptidase M1 family, specifically those acting on ether bonds (ether hydrolases). LTA4H is bifunctional enzyme which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase. LTA4H participates in arachidonic acid metabolism. LTA4H is inhibited by bestatin and subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. LTA4H binds 1 zinc ion per subunit.