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LTA4H

LTA4H Molecule Information

Name:Leukotriene A-4 hydrolase
Target Synonym:Leukotriene A-4 hydrolase,LTA4,LTA-4 hydrolase,LTA4H,Leukotriene A4 Hydrolase,Testicular Secretory Protein Li 27,Leukotriene A(4) Hydrolase,EC 3.3.2.6,EC:3.3.2.6
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

LTA4H Molecule Synonym Name

LTA4H,LTA4

LTA4H Molecule Background

Leukotriene A4 hydrolase (LTA4H) is a protein which belongs to the peptidase M1 family, specifically those acting on ether bonds (ether hydrolases). LTA4H is bifunctional enzyme which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase. LTA4H participates in arachidonic acid metabolism. LTA4H is inhibited by bestatin and subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. LTA4H binds 1 zinc ion per subunit.

LTA4H References

LTA4H Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ubenimex 1580RB; NK-421; NSC-265489 Approved Nippon Kayaku Bestatin Japan Leukemia, Lymphoid s:4:"null"; 1987-01-01 Leukemia, Lymphoid; Lymphedema; Pulmonary Arterial Hypertension Details

LTA4H Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Acebilustat EP-501; CTX-4430 Phase 2 Clinical Celtaxsys Cystic Fibrosis Details

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