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Brief Information

Target Synonym:PEM,Medullary Cystic Kidney Disease 1 (Autosomal Dominant),Tumor Associated Epithelial Mucin,CD227 Antigen,H23 Antigen,MUC-1/SEC,ADMCKD1,Cancer antigen 15-3,Tumor-associated mucin,MUC1-alpha,MUC1-beta,MUC-1/X,MUC1/ZD,Mucin-1,ADMCKD,MCKD1,MAM6,MCKD,MCD,Polymorphic epithelial mucin,PUM,MUC1-NT,Episialin,CD227,MUC1-CT,MUC1,Mucin 1, Cell Surface Associated,Tumor-Associated Epithelial Membrane Antigen,Peanut-Reactive Urinary Mucin,Carcinoma-Associated Mucin,Krebs Von Den Lungen-6,CA 15-3,H23AG,MUC-1,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

MU1-HA2H8-Cell-based assay
 Mucin-1 FACS

5e5 of anti-Mucin-1 (F1C) CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Mucin-1 Protein, His Tag (Cat. No. MU1-HA2H8) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

MU1-H82E5-Cell-based assay
 Mucin-1 FACS

2e5 of Anti-Mucin-1 CAR-293 cells were stained with 100 μL of 0.1 μg/mL of Biotinylated Human Mucin-1, His,Avitag (Cat. No. MU1-H82E5) and negative control protein respectively, washed and then followed by PE-SA and analyzed with FACS (Routinely tested).

 Mucin-1 ELISA

Immobilized Human Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Mucin-1 Antibody, Mouse IgG1 (SM-3) with a linear range of 0.5-4 ng/mL (QC tested).

Mucin-1 MALS images

The purity of Human Mucin-1 (24-380) Protein, His Tag (Cat. No. MU1-H52H7) is more than 90% and the molecular weight of this protein is around 45-65 kDa verified by SEC-MALS.

Synonym Name

Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin


Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Cancer vaccine (BN ImmunoTherapeutics/National Cancer Institute) CVAC-301; CV-301 Phase 2 Clinical Therion Biologics Ovarian Neoplasms; Cystadenocarcinoma; Intestinal Neoplasms; Solid tumours; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Neoplasm Metastasis; Melanoma Details
Anti-MUC1 CAR T cell (Guangzhou Anjie Biomedical) Phase 2 Clinical Guangzhou Anjie Biomedical Technology Esophageal Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Anti-MUC1 monoclonal antibody (OncoQuest) AR20.5; mAb-AR20.5; Anti-MUC1 AR20.5 Phase 2 Clinical Altarex Pancreatic Neoplasms Details
Adenoviral MUC1 vaccine (Etubics) ETBX-061; Ad5-MUC1 Phase 2 Clinical Etubics Corp, Immunitybio Inc, Nantkwest Inc Chordoma; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Lung Neoplasms; Lymphoma, Non-Hodgkin; Colorectal Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell Details
GO-2032c GO-203-2C Phase 2 Clinical Genus Oncology Llc, Dana-Farber Cancer Institute Solid tumours; Multiple Myeloma; Leukemia, Myeloid, Acute Details
MUC1-Poly-ICLC MUC1-poly-ICLC Phase 2 Clinical University Of Pittsburgh Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BLP25 liposome vaccine BLP-25; L-BLP25; ONO-7165; LP-BLP-25; EMD-531444 Phase 2 Clinical Cascadian Therapeutics Inc Rectal Neoplasms; Small Cell Lung Carcinoma; Multiple Myeloma; Breast Neoplasms; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
DS-3939 DS-3939; DS-3939a Phase 2 Clinical Daiichi Sankyo Inc Solid tumours; Neoplasm Metastasis Details
BromAc Phase 2 Clinical Mucpharm Pty Ltd Coronavirus Disease 2019 (COVID-19); Pneumonia, Ventilator-Associated Details
BM7PE Phase 2 Clinical Oslo University Hospital Colorectal Neoplasms Details
Anti-MUC1 CAR T-cell therapy (Guangzhou Anjie Biomedical Technology/University of Technology Sydney) Phase 2 Clinical The First Affiliated Hospital Of Guangdong Pharmaceutical University, Guangzhou Anjie Biomedical Technology, University of Sydney Carcinoma, Non-Small-Cell Lung Details
huMNC2-CAR44 huMNC2-CAR44 Phase 1 Clinical Minerva Biotechnologies Breast Neoplasms Details
Anti MUC 1 chimeric antigen receptor T cell therapy (Innovative Cellular) Phase 1 Clinical Innovative Cellular Therapeutics Co Ltd Pancreatic Neoplasms; Breast Neoplasms; Lung Neoplasms Details
Gatipotuzumab GT-MAB-2.5-GEX Phase 1 Clinical Nemod, Glycotope Gmbh Solid tumours; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
P-MUC1C-ALLO1 P-MUC1C-ALLO1; P-MUC1C-101 Phase 1 Clinical Poseida Therapeutics Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Pancreatic Neoplasms; Nasopharyngeal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MUC1-peptide-DC-CTL (Beijing Doing Biomedical) Phase 1 Clinical Beijing Doing Biomedical Co Ltd Stomach Neoplasms Details
MUC1-gene-DC-CTL (Beijing Doing Biomedical) Phase 1 Clinical Beijing Doing Biomedical Co Ltd Stomach Neoplasms Details
Recombinant HSP-MUC1 fusion protein (Newsummit) Phase 1 Clinical Shanghai Xinshengyuan Biological Medicine Co Ltd Breast Neoplasms Details
DXC-005 DXC-005 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours Details
M-1231 M-1231 Phase 1 Clinical Emd Serono Research & Development Institute Inc, Merck Serono Solid tumours; Esophageal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
ICTCAR-046 ICTCAR-046 Clinical Innovative Cellular Therapeutics Co Ltd Pancreatic Neoplasms Details

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