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Your Position: Home > BMP-2

BMP-2

Brief Information

Name:Bone morphogenetic protein 2
Target Synonym:Bone Morphogenetic Protein 2,BMP-2,Bone morphogenetic protein 2A,BDA2,SSFSC,BMP-2A,BMP2A
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Phase 1 Clinical

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By Tag:
Cat. No. Species Product Description Structure Purity Feature
BM2-H4117 Human Human BMP-2 Protein, Tag Free
BM2-H4117-structure
BM2-H4117-sds

Part of Bioactivity data

BM2-H4117-Cell-based assay
 BMP-2 CELL

Human BMP-2, Tag Free(Cat. No. BM2-H4117) induces alkaline phosphatase production in ATDC5 cells. The EC50 for this effect is 1684-1736 ng/ml (Routinely tested).

BM2-H4117-SPR
 BMP-2 ELISA

Immobilized Human BMP-2, Tag Free (Cat. No. BM2-H4117) at 2 μg/mL (100 μL/well) can bind Human Gremlin, Fc Tag (Cat. No. GR1-H5254) with a linear range of 1-16 ng/mL (QC tested).

Synonym Name

BMP2,BMP2A

Background

Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LH-021 LH-021 Phase 1 Clinical Link Health Group Osteoarthritis Details

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