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Neuropilin-1

Neuropilin-1 Molecule Information

Name:Neuropilin-1
Target Synonym:NRP1,CD304,VEGF165R,Neuropilin 1,Vascular Endothelial Cell Growth Factor 165 Receptor,NRP,Transmembrane Receptor,CD304 Antigen,BDCA4,NP1,Neuropilin-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Pending

Neuropilin-1 Protein Product ListCompare or Buy

Neuropilin-1 Part of Bioactivity data

NR1-H5253-ELISA
Human Neuropilin-1, Mouse IgG2a Fc TagHuman Neuropilin-1, Mouse IgG2a Fc Tag (Cat. No. NR1-H5253) ELISA bioactivity

Immobilized Human VEGF165, His Tag (Cat. No. VE5-H5248) at 2 μg/mL (100 μL/well) can bind Human Neuropilin-1, Mouse IgG2a Fc Tag (Cat. No. NR1-H5253) with a linear range of 0.2-5 ng/mL (QC tested).

NR1-H5253-MALS-HPLC
Human Neuropilin-1, Mouse IgG2a Fc Tag (Cat. No. ) MALS images

The purity of Human Neuropilin-1, Mouse IgG2a Fc Tag(Cat. No. NR1-H5253) was more than 90% and the molecular weight of this protein is around 230-250 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human Neuropilin-1, Mouse IgG2a Fc TagHuman Neuropilin-1, Mouse IgG2a Fc Tag (Cat. No. NR1-H5253) ELISA bioactivity

Immobilized Human VEGF165, His Tag (Cat. No. VE5-H5248) at 2 μg/mL (100 μL/well) can bind Human Neuropilin-1, Mouse IgG2a Fc Tag (Cat. No. NR1-H5253) with a linear range of 0.2-5 ng/mL (QC tested).

Neuropilin-1 Molecule Synonym Name

NRP1,Neuropilin-1,NRP,VEGF165R,CD304

Neuropilin-1 Molecule Background

Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Neuropilin-1 References

Neuropilin-1 Related Molecule

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