Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
Partnering with Diagnostic Biochips, we now provide solutions for in vivo electrophysiology recordings, including high-quality multi-channel electrodes and other products to facilitate high-quality, efficient analysis of neural circuit structure and function.
Protein markers are an essential component in biological research and drug development. Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency.
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins.
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. Explore our isotype controls for your research.
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. Explore our comprehensive collection of recombinant Fc receptor proteins!
Pseudoviruses are virus particles that have altered nucleic acid sequences within their genome to ensure they are replication-deficient and non-pathogenic. Explore our catalog of pseudoviruses & services!
TrkC tyrosine kinase is also known as Trk-C receptor, NT-3 growth factor receptor and neurotrophic tyrosine kinase receptor type 3, is a member of the NTRK family which mediates the biological activities of neurotrophins. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. TrkC is part of the large family of receptor tyrosine kinases which includes TrkA and TrkB. Also, there are other neurotrophic factors structurally related to NT-3: NGF, BDNF and NT-4. While TrkB mediates the effects of BDNF, NT-4 and NT-3, TrkA is bound and thereby activated only by NGF. Further, TrkC binds and is activated only by NT-3. TrkB binds BDNF and NT-4 more strongly than it binds NT-3. TrkC binds NT-3 more strongly than TrkB does. Upon neurotrophin binding, TrkC phosphorylates itself and down stream molecules of the related pathways, and therefore mediates the NT3-stimulated neurotrophic effects. This protein thus leads to cell proliferation, differentiation and plays a role in the development of proprioceptive neurons.