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Brief Information

Target Synonym:Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1),Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein,Secreted Phosphoprotein 1 Variant 6,SPP1/CALPHA1 Fusion,ETA-1,BSPI,SPP-1,Bone sialoprotein 1,BNSP,Urinary stone protein,PSEC0156,OPN,Uropontin,SPP1,Secreted Phosphoprotein 1,Early T-Lymphocyte Activation 1,Nephropontin,Osteopontin,Bone Sialoprotein I
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Part of Bioactivity data

 Osteopontin ELISA

Immobilized Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52E3) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Osteopontin, His,Avitag (Cat. No. OPN-H82E8) with a linear range of 0.078-5 μg/mL (Routinely tested).

Synonym Name



Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Clinical and Translational Updates

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