PDGF R beta Protein - ACROBiosystems

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PDGF R beta

PDGF R beta Protein Product ListCompare or Buy


PDB-H5252	Human	Human PDGF R beta / CD140b Protein, Fc Tag
PDB-H5220	Human	Human PDGF R beta / CD140b Protein, His Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

PDB-H5252

Human

Human PDGF R beta / CD140b Protein, Fc Tag

PDB-H5220

Human

Human PDGF R beta / CD140b Protein, His Tag

PDGF R beta Part of Bioactivity data

PDB-H5220-ELISA

Immobilized Human PDGFRB, His Tag (Cat. No. PDB-H5220) at 2 μg/mL (100 μL/well) can bind Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) with a linear range of 0.5-8 ng/mL (QC tested).

Protocol

PDB-H5252-ELISA

Immobilized Human PDGF-BB, Tag Free (Cat. No. PDB-H4112) at 5 μg/mL (100 μL/well) can bind Human PDGFRB, Fc Tag (Cat. No. PDB-H5252) with a linear range of 0.078-0.625 μg/mL (QC tested).

Protocol

PDGF R beta Molecule Synonym Name

PDGFRB,CD140B,JTK12,PDGF-R-beta,PDGFR-2,PDGFR-beta,PDGFR-¦Â

PDGF R beta Molecule Background

Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called J03278, M21616, CD140B, JTK12, PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB and has a tyrosine-protein kinase activity. Is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D). The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs). Other class III RTKs are CSF1R, KIT and FLT3. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the ¦Á and ¦Â receptors is independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist. The ligands form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their