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Your Position: Home > PDGF R beta

PDGF R beta

Brief Information

Name:Platelet-derived growth factor receptor beta
Target Synonym:EC:2.7.10.1,PDGFRB,Platelet Derived Growth Factor Receptor Beta,Platelet-Derived Growth Factor Receptor, Beta Polypeptide,Beta-Type Platelet-Derived Growth Factor Receptor,PDGFR-Beta,PDGFR,Activated Tyrosine Kinase PDGFRB,CD140b Antigen,NDEL1-PDGFRB,EC 2.7.10.1,CD140B,JTK12,PENTT,IMF1,KOGS,IBGC4,Receptor, Platelet-Derived Growth Factor beta,Beta platelet-derived growth factor receptor,EC 2.7.10,CD140 antigen-like family member B,PDGFR-1,PDGF-R-beta,PDGFR1,Platelet-derived growth factor receptor
Number of Launched Drugs:10
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
PDB-H5259 Human Human PDGF R beta / CD140b Protein, Fc Tag
PDB-H5259-structure
PDB-H5259-sds

Part of Bioactivity data

PDB-H5259-SPR
Human PDGF R beta, Fc TagHuman PDGF R beta, Fc Tag (Cat. No. PDB-H5259) ELISA bioactivity

Immobilized Human PDGF-BB, Tag Free (Cat. No. PDB-H4112) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.6-10 ng/mL (QC tested).

Protocol

Synonym Name

PDGFRB,CD140B,JTK12,PDGF-R-beta,PDGFR-2,PDGFR-beta,PDGFR-¦Â

Background

Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called J03278, M21616, CD140B, JTK12, PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB and has a tyrosine-protein kinase activity. Is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D). The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs). Other class III RTKs are CSF1R, KIT and FLT3. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the ¦Á and ¦Â receptors is independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist. The ligands form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their

Related Molecule

PDGF-B

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Becaplermin biosimilar (Virchow Group) Approved Virchow Group Healace, Plermin gel Diabetic Foot Details
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt EU Leukemia, Myeloid, Acute; Mastocytosis Novartis Europharm Ltd 2017-04-28 Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Regorafenib DAST; BAY-73-4506 Approved Bayer Ag Resihance, Stivarga Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Solid tumours; Carcinoma, Renal Cell; Rectal Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Becaplermin RWJ-60235; rhPDGF-BB (Janssen) Approved Janssen Global Services Llc Regranex United States Ulcer; Lower extremity diabetic neuropathic ulcers Smith & Nephew Healthcare Ltd 1997-12-16 Diabetic Foot; Lower extremity diabetic neuropathic ulcers; Diabetic Neuropathies; Skin Ulcer; Parkinson Disease; Foot Ulcer; Ulcer Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef Mainland China Idiopathic Pulmonary Fibrosis Boehringer Ingelheim International Gmbh 2014-10-15 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Multiple Myeloma; Prostatic Neoplasms; Peritoneal Neoplasms; Hepatic Insufficiency; Genital Neoplasms, Female; Colorectal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Small Cell Lung Carcinoma Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Endometrial Neoplasms; Cholangiocarcinoma; Nasopharyngeal Carcinoma; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Sarcoma, Alveolar Soft Part; Gallbladder Neoplasms; Medullary thyroid cancer (MTC); Thyroid Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Osteoma; Carcinoma, Renal Cell; Head and Neck Neoplasms; Solid tumours; Biliary Tract Neoplasms; Ovarian Neoplasms; Thoracic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Genital Diseases, Female; Leiomyosarcoma; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Sarcoma; Bile Duct Diseases Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc 多吉美, Nexavar EU Thyroid Neoplasms Bayer Ag 2005-12-01 Breast Neoplasms; Neoplasm Metastasis; Fasting; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Thyroid Neoplasms; Hepatitis C; Hepatitis B; Liver Neoplasms; Liver Diseases; Pancreatic Neoplasms; Kidney Diseases; Carcinoma; Carcinoma, Renal Cell; Kidney Neoplasms; Solid tumours; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Details
Dasatinib Hydrate BMS-354825; NSC-732517 Approved Bristol-Myers Squibb Company 施达赛, Spricel, Sprycel, Spraysel Mainland China Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Bristol-Myers Squibb Pharma Eeig 2006-06-28 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid; Leukemia, Lymphoid; Myelodysplastic Syndromes; Scleroderma, Systemic; Blast Crisis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Acute; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Breast Neoplasms; Retinal Vein Occlusion; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Diabetic macular oedema; Prostatic Neoplasms; Kidney Neoplasms; Neuroendocrine Tumors; Urologic Diseases; Kidney Diseases; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Stomach Neoplasms; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Liver Neoplasms; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CLS-1002 CLS-1002 Phase 1 Clinical Clearside Biomedical Macular Degeneration Details
Lucitanib AL-3810; CO-3810; S-80881 Phase 3 Clinical Advenchen Laboratories Nanjing Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Breast Neoplasms; Nasopharyngeal Carcinoma; Colorectal Neoplasms; Thymus Neoplasms; Genital Neoplasms, Female; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer Ag Solid tumours; Stomach Neoplasms Details
Hydroxychloroquine/Sorafenib Phase 1 Clinical Vg Life Sciences Ovarian Neoplasms Details
Crenolanib Besylate ARO-002; CP-868596; ARO-002-26; IND-112201; CP-868596-26 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Glioma; Carcinoma, Non-Small-Cell Lung Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Xiansheng Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
KDR2-2 Phase 2 Clinical Guangzhou Huiborui Biomedical Technology Co Ltd Glaucoma, Neovascular; Corneal Neovascularization Details
Chiauranib CS-2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Solid tumours; Ovarian Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
Metarafenib Phase 1 Clinical Guangzhou Nanxin Pharma Co Ltd Liver Neoplasms; Solid tumours; Carcinoma, Renal Cell; Colonic Neoplasms Details
MG-D-1609 MG-D-1609 Phase 2 Clinical Metagone Biotech Solid tumours Details
Sorafenib/MG-005 MGD-1509; MG-D-1509 Phase 1 Clinical Metagone Biotech, Tri-Service General Hospital Solid tumours Details

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