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Your Position: Home > BTLA

BTLA

Brief Information

Name:B- and T-lymphocyte attenuator
Target Synonym:BTLA,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,B And T Lymphocyte Associated,CD272 Antigen,BTLA1,CD272
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
BTA-H5254 Human Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc Tag (MALS verified)
BTA-H5254-structure
BTA-H5254-sds
BTA-H82E4 Human Biotinylated Human BTLA (31-150) Protein, His,Avitag™ (MALS verified)
BTA-H82E4-structure
BTA-H82E4-sds
BTA-H82F5 Human Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc,Avitag™ (MALS verified)
BTA-H82F5-structure
BTA-H82F5-sds
BTA-H52H5 Human Human BTLA (31-150) (M105V, G138S, V148M) Protein, His Tag (MALS verified)
BTA-H52H5-structure
BTA-H52H5-sds
BTA-H82E5 Human Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, His,Avitag™ (MALS verified)
BTA-H82E5-structure
BTA-H82E5-sds
BTA-H52H3 Human Human BTLA (31-150) Protein, His Tag (MALS verified)
BTA-H52H3-structure
BTA-H52H3-sds
BTA-H5258 Human Human BTLA (31-150) Protein, Mouse IgG2a Fc Tag (MALS verified)
BTA-H5258-structure
BTA-H5258-sds
BTA-H82F3 Human Biotinylated Human BTLA (31-150) Protein, Fc,Avitag™ (MALS verified)
BTA-H82F3-structure
BTA-H82F3-sds
BTA-H82F8 Human Biotinylated Human BTLA (31-134) Protein, Fc,Avitag™
BTA-H82F8-structure
BTA-H82F8-sds
BTA-M5253 Mouse Mouse BTLA Protein, Fc Tag (MALS verified)
BTA-M5253-structure
BTA-M5253-sds
BTA-M52E2 Mouse Mouse BTLA Protein, His Tag
BTA-M52E2-structure
BTA-M52E2-sds
BTA-H5256 Human Human BTLA (31-150) Protein, Fc Tag (MALS verified)
BTA-H5256-structure
BTA-H5256-sds
BTA-H5255 Human Human BTLA (31-134) Protein, Fc Tag
BTA-H5255-structure
BTA-H5255-sds
ACRO Quality

Part of Bioactivity data

BTA-H52H3-BLI
BTLA BLI

Loaded Human BTLA (31-150), His Tag (Cat. No. BTA-H52H3) on NTA Biosensor, can Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. HVM-H5255) with an affinity constant of 20.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
BTA-H82E4-ELISA
BTLA ELISA

Immobilized Biotinylated Human BTLA (31-150), His,Avitag (Cat. No. BTA-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. HVM-H5255) with a linear range of 2-78 ng/mL (QC tested).

Protocol

Synonym Name

BTLA,CD272

Background

B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.

Clinical and Translational Updates

Related Molecule

HVEM B7-H4

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ANB-032 ANB-032 Phase 1 Clinical Anaptysbio Inc Inflammation Details
LY-3361237 LY-3361237 Phase 2 Clinical Eli Lilly And Company, Sanford-Burnham Medical Research Institute Lupus Erythematosus, Systemic; Psoriasis Details
Tifcemalimab TAB-004; JS-004 Phase 2 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Nasopharyngeal Carcinoma; Lung Neoplasms; Lymphoma; Neoplasm Metastasis; Melanoma Details

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