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Your Position: Home > BTLA

BTLA

Brief Information

Name:B- and T-lymphocyte attenuator
Target Synonym:BTLA,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,B And T Lymphocyte Associated,CD272 Antigen,BTLA1,CD272
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
BTA-H52H3 Human Human BTLA (31-150) Protein, His Tag (MALS verified)
BTA-H52H3-structure
BTA-H52H3-sds
BTA-H5258 Human Human BTLA (31-150) Protein, Mouse IgG2a Fc Tag
BTA-H5258-structure
BTA-H5258-sds
BTA-H82E6 Human Biotinylated Human BTLA (31-150) Protein, His,Avitag™
BTA-H82E6-structure
BTA-H82E6-sds
BTA-H82F3 Human Biotinylated Human BTLA (31-150) Protein, Fc,Avitag™
BTA-H82F3-structure
BTA-H82F3-sds
BTA-H82F8 Human Biotinylated Human BTLA (31-134) Protein, Fc,Avitag™
BTA-H82F8-structure
BTA-H82F8-sds
BTA-M5253 Mouse Mouse BTLA Protein, Fc Tag
BTA-M5253-structure
BTA-M5253-sds
BTA-M52E2 Mouse Mouse BTLA Protein, His Tag
BTA-M52E2-structure
BTA-M52E2-sds
BTA-H5256 Human Human BTLA (31-150) Protein, Fc Tag
BTA-H5256-structure
BTA-H5256-sds
BTA-H5255 Human Human BTLA (31-134) Protein, Fc Tag
BTA-H5255-structure
BTA-H5255-sds

Part of Bioactivity data

BTA-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human BTLA (31-150), His Tag (Cat. No. BTA-H52H3) on NTA Biosensor, can Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. HVM-H5255) with an affinity constant of 20.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
BTA-H5258-ELISA
Human BTLA (31-150), Mouse IgG2a Fc TagHuman BTLA (31-150), Mouse IgG2a Fc Tag (Cat. No. BTA-H5258) ELISA bioactivity

Immobilized Human HVEM, His Tag (Cat. No. HVM-H52E9) at 5 μg/mL (100 μL/well) can bind Human BTLA (31-150), Mouse IgG2a Fc Tag (Cat. No. BTA-H5258) with a linear range of 10-156 ng/mL (QC tested).

Protocol

Synonym Name

BTLA,CD272

Background

B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.

Clinical and Translational Updates

Related Molecule

HVEM B7-H4

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LY-3361237 LY-3361237 Eli Lilly And Company, Sanford-Burnham Medical Research Institute Details
Tifcemalimab TAB-004; JS-004 Phase 2 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Lung Neoplasms; Lymphoma; Melanoma Details

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