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Brief Information

Name:Teratocarcinoma-derived growth factor 1
Target Synonym:TDGF1,Cripto-1 Growth Factor,CR-1,CRIPTO,CRGF,Teratocarcinoma-Derived Growth Factor 1,Epidermal Growth Factor-Like Cripto Protein CR1,CR
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

Synonym Name



Teratocarcinoma-derived growth factor 1 (TDGF1) is also known as Cripto-1 growth factor (CRGF), Epidermal growth factor-like cripto protein CR1, CRIPTO, is a cell membrane which contains one EGF-like domain. TDGF1 is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 interacts with the activin type-1 receptor ACVR1B. TDGF1 could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Clinical and Translational Updates

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