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Brief Information

Name:Tumor necrosis factor receptor superfamily member 1A
Target Synonym:Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,CD120a,TNF Receptor Superfamily Member 1A,TNFAR,Tumor Necrosis Factor Receptor Superfamily Member 1A,TNF-R-I,TNF-R55,TNFR60,TNF-R,TNFR1,Tumor Necrosis Factor Receptor Superfamily, Member 1A,Tumor Necrosis Factor Receptor 1A Isoform Beta,Tumor Necrosis Factor Binding Protein 1,Tumor Necrosis Factor Receptor Type 1,Tumor Necrosis Factor Receptor Type I,Tumor Necrosis Factor-Alpha Receptor,Tumor Necrosis Fac
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
TN1-H5251 Human Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag (MALS verified)
TN1-H5222 Human Human TNFR1 / CD120a / TNFRSF1A Protein, His Tag
ACRO Quality

Part of Bioactivity data


Immobilized Human TNF-alpha, premium grade (Cat. No. TNA-H4211) at 2 μg/mL (100 μL/well) can bind Human TNFR1, His Tag (Cat. No. TN1-H5222) with a linear range of 3-25 ng/mL (QC tested).

TNFR1 MALS images

The purity of Human TNFR1, Fc Tag (Cat. No. TN1-H5251) is more than 85% and the molecular weight of this protein is around 100-122 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name



Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ofranergene obadenovec VB-111; GT-111 Phase 3 Clinical Vascular Pharmaceuticals Inc Ovarian Neoplasms; Thyroid Carcinoma, Anaplastic; Neoplasms; Glioblastoma; Neuroendocrine Tumors; Colorectal Neoplasms Details
Atrosab Phase 1 Clinical Celonic Inflammation Details

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