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TNFR1

Brief Information

Name:Tumor necrosis factor receptor superfamily member 1A
Target Synonym:Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,CD120a,TNF Receptor Superfamily Member 1A,TNFAR,Tumor Necrosis Factor Receptor Superfamily Member 1A,TNF-R-I,TNF-R55,TNFR60,TNF-R,TNFR1,Tumor Necrosis Factor Recep
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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By Product Category:
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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
TN1-H5251 Human Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag
TN1-H5251-structure
TN1-H5251-sds
TN1-H5251-elisa_1
TN1-H5222 Human Human TNFR1 / CD120a / TNFRSF1A Protein, His Tag
TN1-H5222-structure
TN1-H5222-sds
TN1-H5222-elisa_1

Part of Bioactivity data

TN1-H5222-ELISA
Human TNFR1, His TagHuman TNFR1, His Tag (Cat. No. TN1-H5222) ELISA bioactivity

Immobilized ActiveMax® Human TNF-alpha, Tag Free, low endotoxin (HPLC-verified) (Cat. No. TNA-H4211) at 2 μg/mL (100 μL/well) can bind Human TNFR1, His Tag (Cat. No. TN1-H5222) with a linear range of 3-25 ng/mL (QC tested).

TN1-H5251-ELISA
Human TNFR1, Fc TagHuman TNFR1, Fc Tag (Cat. No. TN1-H5251) ELISA bioactivity

Immobilized Human TNF-alpha, Tag Free, low endotoxin (Cat. No. TNA-H4211) at 2 μg/mL (100 μL/well) can bind Human TNFR1, Fc Tag (Cat. No. TN1-H5251) with a linear range of 0.2-6 ng/mL (QC tested).

Customer Reviews

Synonym Name

TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60

Background

Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GSK-2862277 GSK-2862277; 2862277 Phase 2 Clinical Glaxosmithkline Plc Respiration Disorders; Respiratory Distress Syndrome, Adult; Acute Lung Injury Details

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