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TNFR1

TNFR1 Product List

Cat. No. Species Product Description Structure Purity Feature
TN1-H5222 Human Human TNFR1 / CD120a / TNFRSF1A Protein
TN1-H5222-structure
TN1-H5222-sds
TN1-H5222-elisa_1
TN1-H5251 Human Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag
TN1-H5251-structure
TN1-H5251-sds
TN1-H5251-elisa_1

TNFR1 Molecule Synonym Name

TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60

TNFR1 Molecule Background

Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

TNFR1 References

TNFR1 Related Molecule

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