Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Thrombopoietin R

Thrombopoietin R

Brief Information

Name:Thrombopoietin receptor
Target Synonym:CD110 Antigen,THCYT2,C-MPL,CD110,MPLV,Receptors, Thrombopoietin,MPL,TPOR,Myeloproliferative leukemia protein,Myeloproliferative Leukemia Virus Oncogene,Proto-Oncogene C-Mpl,TPO-R,MPL Proto-Oncogene, Thrombopoietin Receptor,Thrombopoietin Receptor,THPOR
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
THR-M52H3 Mouse Mouse Thrombopoietin R Protein, His Tag (MALS & SPR verified)
THR-H52H7 Human Human Thrombopoietin R / TPO R Protein, His Tag (MALS & SPR verified)
ACRO Quality

Part of Bioactivity data

 Thrombopoietin R SPR

Mouse Thrombopoietin R Protein, His Tag (Cat. No. THR-M52H3) capture on NTA-Series S sensor chip can bind Human Thrombopoietin Protein, Tag Free (Cat. No. THN-H5214) with an affinity constant of 5.67 nM as determined in a SPR assay (Biacore 8K) (QC tested).

 Thrombopoietin R SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, premium grade (Cat. No. THN-H5214) with an affinity constant of 2.32 nM as determined in SPR assay (Biacore T200) (QC tested).

Synonym Name



Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human thrombopoietin biosimilar (Biolotus) Approved Biolotus Zypotin-TPO Brazil Thrombocytopenia Biolotus 2015-01-01 Thrombocytopenia Details
Romiplostim AMP-2; AMG-531 Approved Amgen Inc Romiplate, Nplate United States Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic Amgen Inc 2008-08-22 Bone Marrow Failure Disorders; Carcinoma, Non-Small-Cell Lung; Lymphoma; Lung Neoplasms; Lymphoma, Non-Hodgkin; Purpura, Thrombocytopenic; Thrombocytopenia; Acute Radiation Syndrome; Pancytopenia; Anemia, Aplastic; Solid tumours; Multiple Myeloma; Myelodysplastic Syndromes; Hodgkin Disease; Small Cell Lung Carcinoma; Neoplasms; Hematologic Neoplasms; Ovarian Neoplasms; Purpura, Thrombocytopenic, Idiopathic Details
Lusutrombopag S-888711 Approved Shionogi & Co Ltd Mulpleta Japan Thrombocytopenia Shionogi & Co Ltd 2015-09-28 Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Thrombocytopenia Details
Herombopag Olamine SHR-8735; SHR 8735 olamine Approved Jiangsu Hengrui Medicine Co Ltd Hengqu, 恒曲 Mainland China Anemia, Aplastic; Thrombocytopenia Jiangsu Hengrui Medicine Co Ltd 2021-06-16 Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Anemia, Aplastic; Breast Neoplasms; Thrombocytopenia; Carcinoma, Non-Small-Cell Lung Details
Recombinant human thrombopoietin mimetic-fusion protein (Qilu Pharmaceutical) QL-0911 Approved Qilu Pharmaceutical Co Ltd Mainland China Thrombocytopenia Qilu Pharmaceutical Co Ltd 2024-04-02 Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia Details
Eltrombopag Diolamine SB-497115; SB-497115-GR; ETB-115 Approved Glaxosmithkline Plc Revolade, Promacta/Revolade, 瑞弗兰, レボレード, Promacta United States Purpura, Thrombocytopenic, Idiopathic Novartis Pharma Ag 2008-11-20 Hepatitis C; Hemorrhage; Liver Diseases; Leukemia, Megakaryoblastic, Acute; Blast Crisis; Bone Marrow Failure Disorders; Anemia, Aplastic; Hepatitis B; Leukemia, Basophilic, Acute; Osteosarcoma; Sarcoma; Multiple Myeloma; Primary Myelofibrosis; Leukemia, Myeloid, Chronic-Phase; Thrombocytopenia; Leukemia, Myeloid, Acute; Leukemia, Monocytic, Acute; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Eosinophilic, Acute; Catheter-Related Infections; Purpura; Wiskott-Aldrich Syndrome; HIV Infections; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Bone marrow transplant rejection; Leukemia, Myeloid, Accelerated Phase; Hematopoietic stem cell transplantation (HSCT); Hematologic Neoplasms; Leukemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Purpura, Thrombocytopenic, Idiopathic; Blood Platelet Disorders; Myelodysplastic Syndromes; Liver Cirrhosis; Leukemia, Myelomonocytic, Acute; Neoplasms, Connective and Soft Tissue; Leukemia, Myelomonocytic, Chronic; Fanconi Anemia; Anemi Details
Avatrombopag Maleate YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501 Approved Astellas Pharma Inc Doptelet, 苏可欣 United States Liver Diseases; Thrombocytopenia Akarx Inc 2018-05-21 Purpura, Thrombocytopenic, Idiopathic; Drug-Related Side Effects and Adverse Reactions; Neoplasms; Blood Platelet Disorders; Liver Diseases; Cardiovascular Diseases; Thrombocytopenia; Lymphoma Details
Recombinant human thrombopoietin rhTPO (3SBio) Approved Shenyang Sunshine Pharmaceutical Co Ltd 特比奥, Tpiao, 特比澳 Mainland China Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic Shenyang Sunshine Pharmaceutical Co Ltd 2005-03-10 Purpura, Thrombocytopenic, Idiopathic; Leukemia; Neutropenia; Plasmacytoma; Sepsis; Liver Cirrhosis; Multiple Myeloma; Liver Diseases; Breast Neoplasms; Thrombocytopenia; Lymphoma; Leukemia, Myeloid, Acute; Myelodysplastic-Myeloproliferative Diseases Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Romiplostim biosimilar (Enzene Biosciences) 267639-76-9 Phase 3 Clinical Enzene Biosciences Ltd Purpura, Thrombocytopenic, Idiopathic Details
Romiplostim biosimilar (Intas Pharmaceuticals) Phase 3 Clinical Intas Biopharmaceuticals Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin / thrombopoietin receptor agonist(Soochow University) Phase 3 Clinical The First Affiliated Hospital Of Soochow University Delayed Graft Function Details
Romiplostim biosimilar(Generium) GNR-069 Phase 3 Clinical Cjsc Generium Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin(Peking University People's Hospital) Phase 2 Clinical Peking University People'S Hospital Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin mimetics (Shandong Quangang) Phase 2 Clinical Shandong Quangang Pharmaceutical Co Ltd Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin (CPGJ) Phase 1 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Thrombocytopenia Details
Pegylated thrombopoietin mimetic peptide SF-303; JNJ-26366821; RWJ-800088; PEG-TPOm Phase 1 Clinical Johnson & Johnson Details
Romiplostim biosimilar(Geropharma) GP-40141 Phase 1 Clinical Geropharm Purpura, Thrombocytopenic, Idiopathic Details
SCB-219 SCB-219-M; SCB-219; SCB-219M Phase 1 Clinical Sichuan Sanyecao Bio-Pharmaceutical Co Ltd Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia Details
Recombinant human thrombopoietin mimetic peptide-Fc fusion protein (Beijing Tide Pharmaceutical) Phase 1 Clinical Beijing Tide Pharmaceutical Co Ltd Thrombocytopenia Details
PEGylated thrombopoietin (Chongqing Paijin Bio) Phase 1 Clinical Chongqing Paijin Biotechnology Co Ltd Thrombocytopenia Details
Thrombopoietin agonist (Scripps Research) 3D9 Clinical The Scripps Research Institute Inc Thrombocytopenia Details

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message