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Thrombopoietin R

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Cat. No. Species Product Description Structure Purity Feature
THR-H52H7 Human Human Thrombopoietin R / TPO R Protein, His Tag (MALS verified)
THR-H52H7-structure
THR-H52H7-sds
THR-H52H7-elisa_2

Part of Bioactivity data

THR-H52H7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, Tag Free (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

THR-H52H7-MALS-HPLC
Human Thrombopoietin R, His Tag (Cat. No. ) MALS images

The purity of Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) is more than 95% and the molecular weight of this protein is around 60-74 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, Tag Free (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

MPL,C-MPL,CD110,MPLV,THCYT2,TPOR

Background

Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.

Clinical and Translational Updates

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