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Thrombopoietin R

Brief Information

Name:Thrombopoietin receptor
Target Synonym:CD110 Antigen,THCYT2,C-MPL,CD110,MPLV,Receptors, Thrombopoietin,MPL,TPOR,Myeloproliferative leukemia protein,Myeloproliferative Leukemia Virus Oncogene,Proto-Oncogene C-Mpl,TPO-R,MPL Proto-Oncogene, Thrombopoietin Receptor,Thrombopoietin Receptor,THPOR
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
THR-H52H7 Human Human Thrombopoietin R / TPO R Protein, His Tag (MALS verified)
ACRO Quality

Part of Bioactivity data

 Thrombopoietin R SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, Tag Free (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Thrombopoietin R MALS images

The purity of Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) is more than 90% and the molecular weight of this protein is around 60-74 kDa verified by SEC-MALS.

Synonym Name



Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human thrombopoietin rhTPO (3SBio) Approved Shenyang Sunshine Pharmaceutical Co Ltd 特比奥, Tpiao, 特比澳 Mainland China Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic Shenyang Sunshine Pharmaceutical Co Ltd 2005-03-10 Purpura, Thrombocytopenic, Idiopathic; Leukemia; Neutropenia; Plasmacytoma; Sepsis; Liver Cirrhosis; Multiple Myeloma; Liver Diseases; Breast Neoplasms; Thrombocytopenia; Lymphoma; Leukemia, Myeloid, Acute; Myelodysplastic-Myeloproliferative Diseases Details
Recombinant human thrombopoietin biosimilar (Biolotus) Approved Biolotus Zypotin-TPO Brazil Thrombocytopenia Biolotus 2015-01-01 Thrombocytopenia Details
Lusutrombopag S-888711 Approved Shionogi & Co Ltd Mulpleta Japan Thrombocytopenia Shionogi & Co Ltd 2015-09-28 Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Thrombocytopenia Details
Eltrombopag Diolamine SB-497115; SB-497115-GR; ETB-115 Approved Glaxosmithkline Plc Revolade, Promacta/Revolade, 瑞弗兰, レボレード, Promacta United States Purpura, Thrombocytopenic, Idiopathic Novartis Pharma Ag 2008-11-20 Hepatitis C; Liver Diseases; Leukemia, Megakaryoblastic, Acute; Blast Crisis; Bone Marrow Failure Disorders; Delayed Graft Function; Anemia, Aplastic; Hepatitis B; Leukemia, Basophilic, Acute; Osteosarcoma; Sarcoma; Hemorrhage; Primary Myelofibrosis; Leukemia, Myeloid, Chronic-Phase; Thrombocytopenia; Leukemia, Myeloid, Acute; Leukemia, Monocytic, Acute; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Eosinophilic, Acute; Catheter-Related Infections; Purpura; Wiskott-Aldrich Syndrome; HIV Infections; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Bone marrow transplant rejection; Leukemia, Myeloid, Accelerated Phase; Hematopoietic stem cell transplantation (HSCT); Hematologic Neoplasms; Leukemia; Non-alcoholic Fatty Liver Disease; Purpura, Thrombocytopenic, Idiopathic; Blood Platelet Disorders; Myelodysplastic Syndromes; Liver Cirrhosis; Leukemia, Myelomonocytic, Acute; Neoplasms, Connective and Soft Tissue; Leukemia, Myelomonocytic, Chronic; Fanconi Anemia; Anemia, Diamond-Blackf Details
Romiplostim AMP-2; AMG-531 Approved Amgen Inc Romiplate, Nplate United States Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic Amgen Inc 2008-08-22 Anemia, Aplastic; Carcinoma, Non-Small-Cell Lung; Lymphoma; Lung Neoplasms; Lymphoma, Non-Hodgkin; Purpura, Thrombocytopenic; Thrombocytopenia; Acute Radiation Syndrome; Pancytopenia; Solid tumours; Bone Marrow Failure Disorders; Multiple Myeloma; Myelodysplastic Syndromes; Hodgkin Disease; Neoplasms; Hematologic Neoplasms; Ovarian Neoplasms; Purpura, Thrombocytopenic, Idiopathic Details
Herombopag Olamine SHR-8735 Approved Jiangsu Hengrui Medicine Co Ltd 恒曲 Mainland China Anemia, Aplastic; Thrombocytopenia Jiangsu Hengrui Medicine Co Ltd 2021-06-16 Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Anemia, Aplastic; Breast Neoplasms; Thrombocytopenia; Carcinoma, Non-Small-Cell Lung Details
Avatrombopag Maleate YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501 Approved Astellas Pharma Inc Doptelet, 苏可欣 United States Liver Diseases; Thrombocytopenia Akarx Inc 2018-05-21 Purpura, Thrombocytopenic, Idiopathic; Drug-Related Side Effects and Adverse Reactions; Neoplasms; Blood Platelet Disorders; Liver Diseases; Cardiovascular Diseases; Thrombocytopenia; Lymphoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Romiplostim biosimilar(Generium) GNR-069 Phase 3 Clinical Cjsc Generium Purpura, Thrombocytopenic, Idiopathic Details
Thrombopoietin agonist (Scripps Research) 3D9 Clinical The Scripps Research Institute Inc Thrombocytopenia Details
Recombinant human thrombopoietin mimetics (Shandong Quangang) Phase 1 Clinical Shandong Quangang Pharmaceutical Co Ltd Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin / thrombopoietin receptor agonist(Soochow University) Phase 3 Clinical The First Affiliated Hospital Of Soochow University Delayed Graft Function Details
Recombinant human thrombopoietin(Peking University People's Hospital) Phase 2 Clinical Peking University People'S Hospital Purpura, Thrombocytopenic, Idiopathic Details
SCB-219 SCB-219-M; SCB-219; SCB-219M Phase 1 Clinical Sichuan Sanyecao Bio-Pharmaceutical Co Ltd Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia Details
Pegylated thrombopoietin mimetic peptide SF-303; JNJ-26366821; RWJ-800088; PEG-TPOm Phase 1 Clinical Johnson & Johnson Details
PEGylated thrombopoietin (Chongqing Paijin Bio) Phase 1 Clinical Chongqing Paijin Biotechnology Co Ltd Thrombocytopenia Details
Recombinant human thrombopoietin (CPGJ) Phase 1 Clinical Sunshine Guojian Pharmaceutical (Shanghai) Co Ltd Thrombocytopenia Details
Romiplostim biosimilar (Enzene Biosciences) 267639-76-9 Phase 3 Clinical Enzene Biosciences Ltd Purpura, Thrombocytopenic, Idiopathic Details
Romiplostim biosimilar (Intas Pharmaceuticals) Phase 3 Clinical Intas Biopharmaceuticals Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin mimetic peptide-Fc fusion protein (Beijing Tide Pharmaceutical) Phase 1 Clinical Beijing Tide Pharmaceutical Co Ltd Thrombocytopenia Details

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