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Cat. No. Species Product Description Structure Purity Feature
IG4-H52E4 Human Human IGFBP-4 Protein, His Tag

Part of Bioactivity data

Human IGFBP-4, His TagHuman IGFBP-4, His Tag (Cat. No. IG4-H52E4) ELISA bioactivity

Immobilized Human IGFBP-4, His Tag (Cat. No. IG4-H52E4) at 2 μg/mL (100 μL/well) can bind Human IGF-I, Fc Tag (Cat. No. IG1-H4269) with a linear range of 4-31 ng/mL (QC tested).

Synonym Name



Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.

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