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Brief Information

Target Synonym:Oprelvekin,IL-11,AGIF,Adipogenesis inhibitory factor,Interleukin 11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:

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Cat. No. Species Product Description Structure Purity Feature
IL1-H82E3 Human Biotinylated Human IL-11 Protein, His,Avitag™ (MALS verified)
IL1-H5243 Human Human IL-11 Protein, His Tag

Part of Bioactivity data


Loaded Human IL-11, His Tag (Cat. No. IL1-H5243) on HIS1K Biosensor, can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with an affinity constant of 0.177 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Human IL-11, His TagHuman IL-11, His Tag (Cat. No. IL1-H5243) ELISA bioactivity

Immobilized Human IL-11, His Tag (Cat. No. IL1-H5243) at 5 μg/mL (100 μL/well) can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with a linear range of 1-10 ng/mL (Routinely tested).

Synonym Name


Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.

Clinical and Translational Updates

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