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Your Position: Home > IL-11

IL-11

Brief Information

Name:Interleukin-11
Target Synonym:Oprelvekin,IL-11,Interleukin 11,Adipogenesis inhibitory factor,AGIF
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Part of Bioactivity data

IL1-H5243-BLI
 IL-11 BLI

Loaded Human IL-11, His Tag (Cat. No. IL1-H5243) on HIS1K Biosensor, can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with an affinity constant of 0.177 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL1-H82E3-ELISA
Biotinylated Human IL-11, His,AvitagBiotinylated Human IL-11, His,Avitag (Cat. No. IL1-H82E3) ELISA bioactivity

Immobilized Biotinylated Human IL-11, His,Avitag (Cat. No. IL1-H82E3) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5. μg/well) plate can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with a linear range of 0.4-13 ng/mL (QC tested).

Synonym Name

Background

Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human interleukin-11 (Hangzhou Jiuyuan Gene Engineering Co Ltd ) Approved Hangzhou Jiuyuan Gene Engineering Co Ltd Thrombocytopenia Details

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