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Your Position: Home > IL-11

IL-11

Brief Information

Name:Interleukin-11
Target Synonym:Oprelvekin,IL-11,Interleukin 11,Adipogenesis inhibitory factor,AGIF
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IL1-H5242 Human Human lL-11 Protein, His Tag, Ultra Low Endotoxin
IL1-H5242-structure
IL1-H5242-sds
IL1-C5244 Cynomolgus Cynomolgus IL-11 Protein, His Tag, Ultra Low Endotoxin
IL1-C5244-structure
IL1-C5244-sds
IL1-C82Q3 Cynomolgus Biotinylated Cynomolgus IL-11 Protein, His,Avitag™ (HPLC-verified)
IL1-C82Q3-structure
IL1-C82Q3-sds
IL1-C82Q3-hplc
EP-159 Human IL-11 : IL-11R [Biotinylated] Inhibitor Screening ELISA Kit
IL1-M5243 Mouse Mouse IL-11 Protein, Fc Tag (MALS verified)
IL1-M5243-structure
IL1-M5243-sds
IL1-C5243 Cynomolgus Cynomolgus IL-11 Protein, His Tag
IL1-C5243-structure
IL1-C5243-sds
IL1-H5269 Human Human IL-11 Protein, Fc Tag (MALS verified)
IL1-H5269-structure
IL1-H5269-sds
IL1-H82E3 Human Biotinylated Human IL-11 Protein, His,Avitag™ (MALS verified)
IL1-H82E3-structure
IL1-H82E3-sds
IL1-H5243 Human Human IL-11 Protein, His Tag
IL1-H5243-structure
IL1-H5243-sds
ACRO Quality

Part of Bioactivity data

IL1-H5243-Cell-based assay
IL-11 CELL

Human IL-11 Protein, His Tag (Cat. No. IL1-H5243) stimulates proliferation of STAT3 (Luc) HEK293 Reporter Cell. The specific activity of Human IL-11 Protein, His Tag is＞8.00 x 10^3 U/mg (QC tested).

Protocol
IL1-H5243-BLI
IL-11 BLI

Loaded Human IL-11 Protein, His Tag (Cat. No. IL1-H5243) on HIS1K Biosensor, can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with an affinity constant of 0.177 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
IL1-C5244-ELISA
IL-11 ELISA

Immobilized Cynomolgus IL-11 Protein, His Tag (Cat. No. IL1-C5244) at 5 μg/mL (100 μL/well) can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with a linear range of 20-156 ng/mL (QC tested).

Protocol

Synonym Name

Background

Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human interleukin-11 (Hangzhou Jiuyuan Gene Engineering Co Ltd ) Approved Hangzhou Jiuyuan Gene Engineering Co., Ltd. Thrombocytopenia Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HB-0056 HB-0056; HB0056 Phase 1 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Asthma Details
9MW3811 9MW3811 Phase 1 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours; Neoplasms; Idiopathic Pulmonary Fibrosis; Fibrosis; Pulmonary Fibrosis Details
BI-765423 BI-765423; BI765423 Phase 1 Clinical Boehringer Ingelheim Ltd Details
LASN-03 Lassen Therapeutics Details

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