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Activin RIIB

Activin RIIB Molecule Information

Name:Activin receptor type-2B
Target Synonym:Activin receptor type IIB,ACVR2B,Activin A Receptor Type 2B,Activin A Receptor, Type IIB,Activin Receptor Type-2B,EC 2.7.11.30,ActR-IIB,ACTRIIB,HTX4,EC 2.7.11,EC:2.7.11.30
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ACB-H5226 Human Human Activin RIIB / ACVR2B Protein, His Tag
ACB-H5226-structure
ACB-H5226-sds

Activin RIIB Molecule Synonym Name

ACVR2B,ACTRIIB,MGC116908

Activin RIIB Molecule Background

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

Activin RIIB References

Activin RIIB Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bimagrumab BYM-338 Phase 2 Clinical Morphosys Ag, Novartis Pharma Ag Diabetes Mellitus, Type 2; Myositis, Inclusion Body; Pulmonary Disease, Chronic Obstructive; Sarcopenia Details
BIIB-110 ALG-801; BIIB-110 Phase 1 Clinical Biogen Inc Amyotrophic Lateral Sclerosis; Muscular Atrophy, Spinal Details

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