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Your Position: Home > Activin RIIB

Activin RIIB

Brief Information

Name:Activin receptor type-2B
Target Synonym:EC:2.7.11.30,EC 2.7.11,Activin receptor type IIB,ACVR2B,Activin A Receptor Type 2B,Activin A Receptor, Type IIB,Activin Receptor Type-2B,EC 2.7.11.30,ActR-IIB,ACTRIIB,HTX4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ACB-H82F3 Human Biotinylated Human Activin RIIB Protein, Fc,Avitag™ (MALS verified)
ACB-H82F3-structure
ACB-H82F3-sds
ACB-M52H5 Mouse Mouse Activin RIIB / ACVR2B Protein, His Tag (MALS & SPR verified)
ACB-M52H5-structure
ACB-M52H5-sds
ACB-H5254 Human Human Activin RIIB Protein, Fc Tag (MALS verified)
ACB-H5254-structure
ACB-H5254-sds
ACB-H82E3 Human Biotinylated Human Activin RIIB Protein, His,Avitag™
ACB-H82E3-structure
ACB-H82E3-sds
ACB-H5226 Human Human Activin RIIB / ACVR2B Protein, His Tag (MALS & SPR verified)
ACB-H5226-structure
ACB-H5226-sds
ACRO Quality

Part of Bioactivity data

ACB-H82F3-SPR
Activin RIIB SPR

Biotinylated Human Activin RIIB Protein, Fc,Avitag (Cat. No. ACB-H82F3) immobilized on SA Chip can bind Human Latent Activin A, His Tag (Cat. No. ACA-H424x) with an affinity constant of 46.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
ACB-M52H5-SPR
Activin RIIB SPR

Mouse Activin RIIB Protein, His Tag (Cat. No. ACB-M52H5) immobilized on CM5 Chip can bind Human Latent Activin A, His Tag (Cat. No. ACA-H424x) with an affinity constant of 0.121 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

ACVR2B,ACTRIIB,MGC116908

Background

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bimagrumab BYM-338; LY-3985863 Phase 2 Clinical Morphosys Ag, Novartis Pharma Ag Diabetes Mellitus, Type 2; Myositis, Inclusion Body; Pulmonary Disease, Chronic Obstructive; Obesity; Sarcopenia; Overweight Details
BIIB-110 BIIB-110; BIIB110; ALG-801 Phase 1 Clinical Alivegen USA Inc Muscular Diseases; Muscular Atrophy, Spinal Details
HS135 HS-135 Phase 1 Clinical 35Pharma Inc Hypertension, Pulmonary; Pulmonary Arterial Hypertension Details

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