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CD2 Molecule Information

Name:T-cell surface antigen CD2
Target Synonym:LFA-2;Rosette receptor;SRBC;CD2;T-cell surface antigen CD2;CD_antigen=CD2;Erythrocyte receptor;LFA-3 receptor;T-cell surface antigen T11/Leu-5
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Withdrawn

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Cat. No. Species Product Description Structure Purity Feature
CD2-H5258 Human Human CD2 / SRBC Protein, Fc Tag
CD2-H5226 Human Human CD2 / SRBC Protein, His Tag

CD2 Part of Bioactivity data


Loaded Human CD2, Fc Tag (Cat. No. CD2-H5258) on Protein A Biosensor, can bind Human CD58, His Tag (Cat. No. LF3-H5225) with an affinity constant of 2.3 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).


Loaded bind Human CD58, Fc Tag (Cat. No. LF3-H5256) on Protein A Biosensor, can bind Human CD2, His Tag (Cat. No. CD2-H5226) with an affinity constant of 8.42 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

CD2 Molecule Synonym Name


CD2 Molecule Background

T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I  membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.

CD2 References

CD2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Siplizumab MEDI-507 Phase Ⅱ Catholic University of Louvain, MedImmune Cutaneous T cell lymphoma (CTCL), Psoriasis, Graft versus host disease, Psoriatic arthritis, Rheumatoid arthritis (RA), Peripheral T cell lymphoma (PTCL), Rejection of renal transplantation Details
Alefacept ASP-0485; BG-9273; BG-9712; LFA-3(92)IgG; LFA-3-TIP Withdrawn Astellas Psoriasis Details
BTI 322 BTI-322 Phase Ⅱ University of Leuven, MedImmune Autoimmune diseases, Graft versus host disease, Rejection of liver transplantation, Rejection of renal transplantation Details
TCD-601 TCD-601 Phase Ⅱ ITB-Med Rejection of renal transplantation Details

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