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CD27 Molecule Information

Name:CD27 antigen
Target Synonym:T-cell activation antigen CD27;T14;Tumor necrosis factor receptor superfamily member 7;CD27L receptor;CD27;TNFRSF7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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CD27 Molecule Synonym Name


CD27 Molecule Background

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-¦ÊB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 References

CD27 Related Molecule

CD27 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MK-5890 MK-5890 Phase Ⅱ Merck Sharp & Dohme Non small cell lung cancer (NSCLC) Details
LOR-S03 CDX-527; LOR-A04; LOR-S01; LOR-S03 Preclinical Celldex Cancer Details
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 Phase Ⅰ Aduro BioTech, Merck Sharp & Dohme Solid tumours Details
Varlilumab CDX-1127 Phase Ⅱ Celldex, Cascadian Therapeutics, University of Virginia Solid tumours, Non-Hodgkin's lymphoma (NHL), Glioblastoma, Melanoma Details

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