CD27

CD27 Molecule Information

Name：CD27 antigen
Target Synonym：T-cell activation antigen CD27?T14?Tumor necrosis factor receptor superfamily member 7?CD27L receptor?CD27?TNFRSF7

Number of Launched Drugs：0
Number of Drugs in Clinical Trials：2
Lastest Research Phase：Phase ?

CD27 Protein Product ListCompare or Buy

Cat. No.	Species	Product Description
CD7-H522b	Human	Human CD27 / TNFRSF7 Protein
CD7-M5252	Mouse	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257	Human	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-C5259	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
TN7-H82F6	Human	Biotinylated Human CD27 / TNFRSF7 Protein, Fc Tag, Avi Tag (Avitag™)
CD7-H5254	Human	Human CD27 / TNFRSF7 Protein, Fc Tag

CD27 Molecule Synonym Name

CD27,TNFRSF7,S152,T14,Tp55

CD27 Molecule Background

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-¦ÊB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 References

CD27 Related Molecule

CD27 ligand

CD27 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	Phase Ⅰ	Aduro BioTech, Merck Sharp & Dohme	Solid tumours	Details
Varlilumab	CDX-1127	Phase Ⅱ	Celldex, Cascadian Therapeutics, University of Virginia	Prostate cancer, hematological malignancies, Breast cancer, Solid tumours, Ovarian cancer, Renal carcinoma, Melanoma	Details