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Your Position: Home > CD27

CD27

CD27 Molecule Information

Name:CD27 antigen
Target Synonym:CD27 antigen,Tumor necrosis factor receptor superfamily member 7,CD27L receptor,CD27,CD27 Molecule,T-Cell Activation Antigen CD27,TNFRSF7,T14,T Cell Activation Antigen S152,S152. LPFS2,S152,Tp55,Tumor Necrosis Factor Receptor Superfamily, Member 7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD7-H522b Human Human CD27 / TNFRSF7 Protein, His Tag (MALS Verified)
CD7-H522b-structure
CD7-H522b-sds
CD7-H522b-elisa_1
CD7-M5252 Mouse Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M5252-structure
CD7-M5252-sds
CD7-M5252-elisa_1
CD7-H5257 Human Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257-structure
CD7-H5257-sds
CD7-H5257-elisa_1
CD7-C5259 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-C5259-structure
CD7-C5259-sds
CD7-C5259-elisa_1
TN7-H82F6 Human Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
TN7-H82F6-structure
TN7-H82F6-sds
TN7-H82F6-elisa_1
CD7-H5254 Human Human CD27 / TNFRSF7 Protein, Fc Tag (HPLC verified)
CD7-H5254-structure
CD7-H5254-sds
CD7-H5254-hplc
CD7-H5254-elisa_1

CD27 Part of Bioactivity data

CD7-H5257-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Flow Cytometry assay shows that Human CD27, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H5257) can bind to Raji cells Surface Human CD70. The concentration of CD27 used is 10 μg/mL (Routinely tested).

Protocol
TN7-H82F6-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Flow Cytometry assay shows that Biotinylated Human CD27, Fc,Avitag (Cat. No. TN7-H82F6) can bind to Raji cells Surface Human CD70. The concentration of CD27 used is 10 μg/mL (Routinely tested).

Protocol
CD7-M5252-ELISA
Mouse CD27, Mouse IgG2a Fc Tag, low endotoxinMouse CD27, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-M5252) ELISA bioactivity

Immobilized Mouse CD27, Mouse IgG2a Fc Tag (Cat. No. CD7-M5252) at 2 μg/mL (100 μL/well) can bind Biotinylated Mouse CD70, His Tag, Avi Tag with a linear range of 1-16 ng/mL (QC tested).

Protocol
CD7-H522b-MALS-HPLC
Human CD27, His Tag (Cat. No. ) MALS images

The purity of Human CD27, His Tag (Cat. No. CD7-H522b) was more than 85% and the molecular weight of this protein is around 38-48 kDa verified by SEC-MALS.

Report
Bioactivity-ELISA
Human CD27, His TagHuman CD27, His Tag (Cat. No. CD7-H522b) ELISA bioactivity

Immobilized Human CD27, His Tag (Cat. No. CD7-H522b) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD27 Ligand, Avitag,Fc Tag (Cat. No. TN7-H82F4) with a linear range of 2-31 ng/mL (QC tested).

CD27 Molecule Synonym Name

CD27,TNFRSF7,S152,T14,Tp55

CD27 Molecule Background

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-¦ÊB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 References

CD27 Related Molecule

CD27 ligand

CD27 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 Phase 1 Clinical Aduro Biotech Neoplasms Details
LOR-S03 CDX-527; LOR-A04; LOR-S01; LOR-S03 Phase 1 Clinical Celldex Liver Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Microsatellite instability-high cancer; Urinary Bladder Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Varlilumab CDX-1127 Phase 2 Clinical Celldex Urologic Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Urogenital Neoplasms; Lymphoma; Glioma; Lymphoma, Non-Hodgkin; Urologic Neoplasms; Lymphoma, Mantle-Cell; Prostatic Neoplasms; Ovarian Neoplasms; Urinary Bladder Neoplasms; Triple Negative Breast Neoplasms; Kidney Diseases; Glioblastoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Kidney Neoplasms; Head and Neck Neoplasms; Lymphoma, B-Cell Details
MK-5890 MK-5890 Phase 2 Clinical Merck & Co Inc Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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