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Your Position: Home > CD27

CD27

CD27 Molecule Information

Name:CD27 antigen
Target Synonym:T-cell activation antigen CD27;T14;Tumor necrosis factor receptor superfamily member 7;CD27L receptor;CD27;TNFRSF7

Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

CD27 Part of Bioactivity data

CD7-H5257-Cell-based assay

Human FcRn Heterodimer Protein Cell_Base

Flow Cytometry assay shows that Human CD27, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H5257) can bind to Raji cells Surface Human CD70. The concentration of CD27 used is 10 μg/mL (Routinely tested).

Protocol

TN7-H82F6-Cell-based assay

Flow Cytometry assay shows that Biotinylated Human CD27, Fc,Avitag (Cat. No. TN7-H82F6) can bind to Raji cells Surface Human CD70. The concentration of CD27 used is 10 μg/mL (Routinely tested).

Protocol

CD7-M5252-ELISA

Immobilized Mouse CD27, Mouse IgG2a Fc Tag (Cat. No. CD7-M5252) at 2 μg/mL (100 μL/well) can bind Biotinylated Mouse CD70, His Tag, Avi Tag with a linear range of 1-16 ng/mL (QC tested).

Protocol

CD7-H522b-ELISA

Immobilized Human CD27, His Tag (Cat. No. CD7-H522b) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD27 Ligand, Avitag,Fc Tag (Cat. No. TN7-H82F4) with a linear range of 2-31 ng/mL (QC tested).

Protocol

CD27 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
CD7-H522b	Human	Human CD27 / TNFRSF7 Protein, His Tag
CD7-M5252	Mouse	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257	Human	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-C5259	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
TN7-H82F6	Human	Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
CD7-H5254	Human	Human CD27 / TNFRSF7 Protein, Fc Tag

CD27 Molecule Synonym Name

CD27,TNFRSF7,S152,T14,Tp55

CD27 Molecule Background

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-¦ÊB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 References

CD27 Related Molecule

CD27 ligand

CD27 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
MK-5890	MK-5890	Phase Ⅱ	Merck Sharp & Dohme	Non small cell lung cancer (NSCLC)	Details
LOR-S03	CDX-527; LOR-A04; LOR-S01; LOR-S03	Preclinical	Celldex	Cancer	Details
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	Phase Ⅰ	Aduro BioTech, Merck Sharp & Dohme	Solid tumours	Details
Varlilumab	CDX-1127	Phase Ⅱ	Celldex, Cascadian Therapeutics, University of Virginia	Solid tumours, Non-Hodgkin's lymphoma (NHL), Glioblastoma, Melanoma	Details