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Your Position: Home > CTXB


Brief Information

Name:Toxin B
Target Synonym:EC:3.4.22.-,Toxin B,toxB
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
CTB-V52E8 Vibrio cholerae serotype O1 Vibrio cholerae serotype O1 CTXB Protein, His Tag

Synonym Name



Cholera enterotoxin subunit B (CTXB) is also known as cholera enterotoxin B chain, cholera enterotoxin gamma chain and choleragenoid. Vibrio cholerae O1 exists as two major serotypes, Inaba and Ogawa, which are associated with the O antigen of the lipopolysaccharide and are capable of unequal reciprocal interconversion. The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. CTXB can bind five GM1 gangliosides. Also, it has no toxic activity by itself.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Bezlotoxumab CDB-1; MK-6072; MBL-CDB1; MDX-1388 Approved Merck Sharp & Dohme Corp Zinplava Japan Clostridium Infections; Diarrhea Merck Sharp & Dohme Corp 2016-10-21 Clostridium Infections; Diarrhea Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LMN-201 LMN-201 Clostridium Infections Details
IMM-529 IMM-529 Immuron Details
Ribaxamase SYN-004(Synthetic Biologics) Phase 2 Clinical Synthetic Biologics Graft vs Host Disease Details

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