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IGFBP-7

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Cat. No. Species Product Description Structure Purity Feature
IG7-H5240 Human Human IGFBP-7 Protein, His Tag
IG7-H5240-structure
IG7-H5240-sds
IG7-H5240-elisa_2

Part of Bioactivity data

IG7-H5240-BLI
Human_FcRn_Heterodimer_Protein_SPR

Human IGFBP-7, His Tag (Cat. No. IG7-H5240) immobilized on CM5 Chip can bind Human C1q R1, His Tag (Cat. No. C11-H5228) with an affinity constant of 0.223 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

IBP7,IGFBP7

Background

Insulin-like growth factor-binding protein 7 (IGFBP7) is also known as IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, prostacyclin-stimulating factor and tumor-derived adhesion factor, which contains one Ig-like C2-type (immunoglobulin-like) domain, one IGFBP N-terminal domain and one Kazal-like domain. The major function of IGFBP7 is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity except for IGF-I and IGF-II.IGFBP7 also stimulates cell adhesion. Furthermore, IGFBP7 is implicated in some cancers.

Clinical and Translational Updates

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