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IGFBP-7

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Part of Bioactivity data

IG7-H82Q9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IGFBP-7, His,Avitag (Cat. No. IG7-H82Q9) immobilized on CM5 Chip can bind Human C1q R1, His Tag (Cat. No. C11-H5228) with an affinity constant of 20 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IG7-H82F9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IGFBP-7, Fc,Avitag (Cat. No. IG7-H82F9) immobilized on CM5 Chip can bind Human C1q R1, His Tag (Cat. No. C11-H5228) with an affinity constant of 14.3 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

IBP7,IGFBP7

Background

Insulin-like growth factor-binding protein 7 (IGFBP7) is also known as IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, prostacyclin-stimulating factor and tumor-derived adhesion factor, which contains one Ig-like C2-type (immunoglobulin-like) domain, one IGFBP N-terminal domain and one Kazal-like domain. The major function of IGFBP7 is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity except for IGF-I and IGF-II.IGFBP7 also stimulates cell adhesion. Furthermore, IGFBP7 is implicated in some cancers.

Clinical and Translational Updates

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