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IL-23R Molecule Information

Name:Interleukin 23 Receptor
Target Synonym:IL-23 receptor,IL23R,Interleukin 23 Receptor,Interleukin-23 Receptor,IL-23R
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

IL-23R Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
ILR-H82F3 Human Biotinylated Human IL-23 R Protein, Fc,Avitag™
ILR-H5254 Human Human IL-23 R Protein, Fc Tag
ILR-H52H4 Human Human IL-23 R Protein, His Tag (SPR verified)
ILR-M5251 Mouse Mouse IL-23 R Protein, Fc Tag

IL-23R Part of Bioactivity data


Captured Human IL-23 R, Fc Tag (Cat. No. ILR-H5254) on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL23A & IL12B, His Tag (Cat. No. ILB-H52W5) with an affinity constant of 5.36 nM as determined in a SPR assay (Biacore T200) (Routinely tested).


Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-H82W6) captured on Biotin CAP - Series S sensor Chip can bind Human IL-23 R, His Tag (SPR verified) (Cat. No. ILR-H52H4) affinity constant of 3.39 nM as determined in a SPR assay (Biacore 8K) (QC tested).

IL-23R Molecule Synonym Name

IL-23 R,IL-23 Receptor

IL-23R Molecule Background

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

IL-23R References

IL-23R Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tildrakizumab-asmn SUNPG 1623-II; SUNPG-1623; SUNPG-1622-I; SUNPG-1623-I; MK-3222; SCH-900222; SUNPG-1622; SUNPG-1623-III; SUNPG-1623-IV Approved Merck Sharp & Dohme Corp Ilumetri, Ilumya Japan Plaque psoriasis s:9:"Sun Pharm"; 2018-03-20 Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis Details

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