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VEGF121 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
VE1-H82E7 Human Biotinylated Human VEGF121 Protein, Avitag™,His Tag
VE1-H5246 Human Human VEGF121 Protein, His Tag
VE1-H4213 Human ActiveMax® Human VEGF121 Protein, Tag Free

VEGF121 Part of Bioactivity data

Human VEGF121, His TagHuman VEGF121, His Tag (Cat. No. VE1-H5246) ELISA bioactivity

Immobilized Human VEGFR1/R2, Fc Tag at 1 μg/mL (100 μL/well) can bind Human VEGF121, His Tag (Cat. No. VE1-H5246) with a linear range of 2-40 ng/mL (QC tested).

Biotinylated Human VEGF121, Avitag,His TagBiotinylated Human VEGF121, Avitag,His Tag (Cat. No. VE1-H82E7) ELISA bioactivity

Immobilized VEGFR1/R2-Fc at 1 μg/mL (100 μL/well) can bind Biotinylated Human VEGF121, Avitag,His Tag (Cat. No. VE1-H82E7) with a linear range of 0.1-2 ng/mL (QC tested).

VEGF121 Molecule Synonym Name


VEGF121 Molecule Background

Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor (VPF) and VEGF-A, and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible. Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term, and show defects in skeletogenesis. Human VEGF121 shares 87% aa sequence identity with corresponding regions of mouse and rat, 93% with feline, equine and bovine, and 91%, 95% and 96% with ovine, canine and porcine VEGF, respectively. VEGF121 induces the proliferation of lymphatic endothelial cells. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C.

VEGF121 References

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