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Your Position: Home > VEGF121

VEGF121

Brief Information

Name:Vascular endothelial growth factor A
Target Synonym:Vascular Endothelial Growth Factor,VEGF-A,MVCD1,Vascular endothelial growth factor A,VEGF,VEGFA,VPF,Vascular Endothelial Growth Factor A165,Vascular permeability factor,Vascular Endothelial Growth Factor A121
Number of Launched Drugs:25
Number of Drugs in Clinical Trials:68
Lastest Research Phase:Approved

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Part of Bioactivity data

VE1-H5246-ELISA
Human VEGF121, His TagHuman VEGF121, His Tag (Cat. No. VE1-H5246) ELISA bioactivity

Immobilized Human VEGF121, His Tag (Cat. No. VE1-H5246) at 1 μg/mL (100 μL/well) can bind Human VEGFR1/R2, Fc Tag with a linear range of 0.4-6 ng/mL (QC tested).

VE1-H5246-MALS-HPLC
Human VEGF121, His Tag (Cat. No. ) MALS images

The purity of Human VEGF121, His Tag (Cat. No. VE1-H5246) is more than 90% and the molecular weight of this protein is around 30-45 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human VEGF121, His TagHuman VEGF121, His Tag (Cat. No. VE1-H5246) ELISA bioactivity

Immobilized Human VEGF121, His Tag (Cat. No. VE1-H5246) at 1 μg/mL (100 μL/well) can bind Human VEGFR1/R2, Fc Tag with a linear range of 0.4-6 ng/mL (QC tested).

Synonym Name

RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF

Background

Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor (VPF) and VEGF-A, and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible. Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term, and show defects in skeletogenesis. Human VEGF121 shares 87% aa sequence identity with corresponding regions of mouse and rat, 93% with feline, equine and bovine, and 91%, 95% and 96% with ovine, canine and porcine VEGF, respectively. VEGF121 induces the proliferation of lymphatic endothelial cells. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ranibizumab biosimilar (Intas Biopharmaceuticals) Approved Intas Biopharmaceuticals Razumab India Macular Degeneration Intas Biopharmaceuticals 2015-01-01 Macular Degeneration Details
Ranibizumab biosimilar (Senju) GBS-007; OT-701; SJP-0133 Approved Senju Pharmaceutical Co Ltd Japan Macular Degeneration Senju Pharmaceutical Co Ltd 2021-09-27 Macular Degeneration Details
Bevacizumab biosimilar (Dr. Reddy's Laboratories) Approved Dr Reddy's Laboratories Ltd Versavo India Glioblastoma; Carcinoma, Renal Cell; Peritoneal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms Dr Reddy's Laboratories Ltd 2019-08-19 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Zydus Cadila) Approved Zydus Cadila Bryxta India Carcinoma, Non-Small-Cell Lung Zydus Cadila 2017-01-01 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Metastatic breast cancer; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Hetero Drugs) Approved Hetero Drugs Cizumab India Colorectal Neoplasms Hetero Drugs 2016-06-27 Colorectal Neoplasms Details
Bevacizumab biosimilar(Apotex ) Approved Apotex Inc BAMBEVI Canada Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Glioblastoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Apotex Inc 2021-09-23 Carcinoma, Ovarian Epithelial; Glioblastoma; Peritoneal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Reliance Life Sciences) R-TPR-023 Approved Reliance Life Sciences BevaciRel India Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Glioblastoma; Carcinoma, Renal Cell; Uterine Cervical Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms Reliance Life Sciences Pvt Ltd 2016-06-13 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (AryoGen Biopharma) BE1040V Approved Aryogen Biopharma Stivant Iran Glioblastoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Uterine Cervical Neoplasms; Metastatic breast cancer; Peritoneal Neoplasms; Fallopian Tube Neoplasms Aryogen Biopharma 2019-06-01 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Metastatic breast cancer; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Intas Pharmaceuticals) INTP-24 Approved Intas Biopharmaceuticals Bevatas India Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Uterine Cervical Neoplasms; Glioblastoma; Breast Neoplasms Intas Biopharmaceuticals 2017-10-04 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (TOT Biopharm) TOT-102; TAB008; TOT102; TAB-008 Approved Tot Biopharm Co Ltd 朴欣汀, Pusintin Mainland China Uterine Cervical Neoplasms; Carcinoma, Ovarian Epithelial; Glioblastoma; Fallopian Tube Neoplasms; Peritoneal Neoplasms Tot Biopharm Co Ltd 2021-12-01 Glioblastoma; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Bio-Thera Solutions) BAT-1706 Approved Bio-Thera Solutions Ltd 普贝希 Mainland China Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Glioblastoma; Peritoneal Neoplasms; Uterine Cervical Neoplasms Bio-Thera Solutions Ltd 2021-11-17 Ovarian Neoplasms; Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular Details
Ziv-aflibercept BAY-865321; AVE-0005 Approved Regeneron Pharmaceuticals Inc, Sanofi Zaltrap Japan Colorectal Neoplasms Sanofi 2012-08-03 Colorectal Neoplasms Details
Neovasculgen PI-VEGF165 Approved Human Stem Cells Institute Neovasculgen Russian Federation Peripheral Arterial Disease Human Stem Cells Institute 2011-12-07 Peripheral Arterial Disease Details
Bevacizumab biosimilar (Biocad) BCD-021 Approved Biocad Avegra Russian Federation Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Breast Neoplasms; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Uterine Cervical Neoplasms; Glioblastoma; Carcinoma, Renal Cell Biocad 2015-11-25 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Elea) Approved Laboratorio Elea Phoenix Sa Lumiere Argentina Macular Degeneration Laboratorio Elea Phoenix Sa 2018-04-26 Macular Degeneration Details
Bevacizumab biosimilar (Samsung Bioepis) SP-8; SB-8 Approved Samsung Bioepis Aybintio EU Uterine Cervical Neoplasms; Carcinoma, Renal Cell; Peritoneal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Carcinoma, Ovarian Epithelial Samsung Bioepis Nl Bv 2020-08-19 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ranibizumab biosimilar (Samsung Bioepis) SB-11 Approved Samsung Bioepis BYOOVIZ United States Choroidal Neovascularization; Macular Degeneration; Macular Edema Samsung Bioepis Co Ltd, null 2021-08-18 Macular Edema; Wet Macular Degeneration; Choroidal Neovascularization; Macular Degeneration; Diabetic Retinopathy Details
Bevacizumab biosimilar (Innovent Biologics) IBI-305; IBI305; IBI 305; CHS-305 Approved Innovent Biologics(Suzhou) Co Ltd 达攸同, BYVASDA, Bevagen Indonesia Colorectal Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Ovarian Neoplasms; Uterine Cervical Neoplasms Innovent Biologics(Suzhou) Co Ltd 2020-06-17 Ovarian Neoplasms; Triple Negative Breast Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular Details
Conbercept FP-3; KH-902 Approved Chengdu Kanghong Biotechnologies Co Ltd 朗沐, Langmu Mainland China Macular Degeneration Chengdu Kanghong Biotechnologies Co Ltd 2013-11-27 Macular Edema; Vision Disorders; Diabetic macular oedema; Wet Macular Degeneration; Retinoblastoma; Hemangioma; Uveitis; Corneal Neovascularization; Macular Degeneration; Choroidal Neovascularization; Diabetes Mellitus; Retinal Vein Occlusion Details
Bevacizumab biosimilar (Betta/Mabworks) MIL-60 Approved Institute Of Basic Medicine, Chinese Academy Of Medical Sciences, Beijing Mabworks Biotech Co Ltd 贝安汀 Mainland China Glioblastoma; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Ovarian Epithelial Betta Pharmaceuticals Co Ltd 2021-11-24 Ovarian Neoplasms; Solid tumours; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular Details
Bevacizumab biosimilar (Jiangsu Hengrui Medicine) BP-102 Approved Jiangsu Hengrui Medicine Co Ltd 艾瑞妥 Mainland China Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Suzhou Suncadia Biopharmaceuticals Co Ltd 2021-06-22 Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Biocon/Mylan) MYL-1402O Approved Biocon KRABEVA, Abevmy, Lextemy EU Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Peritoneal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial Mylan Ire Healthcare Ltd 2017-11-27 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Brain Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Allergan/Amgen) ABP-215 Approved Amgen Inc Mvasi United States Fallopian Tube Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms Amgen Inc 2017-09-14 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Boan Biopharma) LY-01008 Approved Shandong Boan Biotechnology Co Ltd 博优诺 Mainland China Uterine Cervical Neoplasms; Carcinoma, Ovarian Epithelial Shandong Boan Biotechnology Co Ltd 2021-05-07 Solid tumours; Ovarian Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Pfizer) PF-6439535; PF-06439535 Approved Pfizer Inc Zirabev United States Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Ovarian Epithelial Pfizer Inc 2019-02-14 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Qilu Pharma) QL-1101 Approved Qilu Pharmaceutical Co Ltd 安可达 Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Qilu Pharmaceutical Co Ltd 2019-12-06 Ovarian Neoplasms; Solid tumours; Breast Neoplasms; Coronavirus Infections; Colorectal Neoplasms; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab G180CU; RO-4876646; RG-435; NSC-704865; G180CL; R-435; G180DL Approved Genentech Inc 安维汀, Avastin Mainland China Carcinoma, Hepatocellular Roche Pharmaceutical Co Ltd 2004-02-26 Retinal Detachment; Endometrial Neoplasms; Esophageal adenocarcinoma; Sarcoma, Alveolar Soft Part; Hemangiopericytoma; Fallopian Tube Neoplasms; Glioma; Astrocytoma; Gliosarcoma; Peritoneal Neoplasms; Colorectal Neoplasms; Vitreous Hemorrhage; Nasopharyngeal Carcinoma; Cholangiocarcinoma; Neuromyelitis Optica; Vitreoretinopathy, Proliferative; Prostatic Neoplasms; Vulvar Neoplasms; Diabetic macular oedema; Sarcoma; Brain Neoplasms; Retinal Vein Occlusion; Corneal Neovascularization; Macular Degeneration; Melanoma; von Hippel-Lindau Disease; Meningioma; Uterine Cervical Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Diabetic Retinopathy; Myopia; Neurofibromatosis 1; Breast Neoplasms; Retinopathy of Prematurity; Choroidal Neovascularization; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Neuroma, Acoustic; Carcinoma, Hepatocellular; Lung Neoplasms; Pleural Effusion, Malignant; Arteriovenous Malformations; Hemangioblastoma; Vaginal Neoplasms; Esophageal Neop Details
Bevacizumab biosimilar (Shanghai Henlius Biotech) HLX-04; HLX04-O Approved Shanghai Henlius Biotech Co Ltd 汉贝泰 Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Shanghai Henlius Biopharmaceuticals Co Ltd 2021-11-30 Rectal Neoplasms; Wet Macular Degeneration; Colorectal Neoplasms; Macular Degeneration; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Ranibizumab RG-3645; rhu-Fab-VEG; AMD-rhuFab-V2; AMD-Fab; rhuFab-V2; RFB-002; Y-0317; RG-6321 Approved Novartis Pharma Ag, Genentech Inc Lucentis, 诺适得, Susvimo Japan Diabetic macular oedema Novartis Pharma Ag 2006-06-30 Ischemia; Retinoblastoma; Vascular Diseases; Glaucoma; Diabetes Complications; Pseudoxanthoma Elasticum; Retinal Detachment; Retinal Neovascularization; Cardiovascular Diseases; Retinal Degeneration; Eye Diseases; Vitreous Hemorrhage; Uveitis; Wet Macular Degeneration; Macular Degeneration; Choroidal Neovascularization; Melanoma; Conjunctival Neoplasms; Diabetic Retinopathy; Diabetes Mellitus; Retinopathy of Prematurity; Retinal Vein Occlusion; Port-Wine Stain; Corneal Neovascularization; von Hippel-Lindau Disease; Myopia; Telangiectasis; Epistaxis; Cataract; Telangiectasia, Hereditary Hemorrhagic; Pterygium; Retinal Telangiectasis; Diabetic Angiopathies; Vitreous Detachment; Iris Diseases; Macular Edema; Vision Disorders; Choroid Diseases; Glaucoma, Neovascular; Optic Neuropathy, Ischemic; Neovascularization, Pathologic; Depression; Central Serous Chorioretinopathy; Histoplasmosis; Myopia, Degenerative; Retinal Diseases; Angioid Streaks; Pathologic Processes; Glaucoma, Open-Angle; Diabetic macular oedema; He Details
Ranibizumab biosimilar (Formycon/Bioeq) FYB-201 Approved Formycon, Bioeq CIMERLI United States Retinal Vein Occlusion; Macular Edema; Wet Macular Degeneration; Diabetic Retinopathy; Choroidal Neovascularization; Diabetic macular oedema Coherus Biosciences Inc 2022-08-02 Macular Edema; Wet Macular Degeneration; Diabetic macular oedema; Retinal Vein Occlusion; Macular Degeneration; Diabetic Retinopathy; Choroidal Neovascularization Details
Faricimab RG-7716; RO-6867461 Approved F. Hoffmann-La Roche Ltd, Genentech Inc Vabysmo Japan Macular Degeneration; Diabetic macular oedema Chugai Pharmaceutical Co Ltd 2022-01-28 Macular Edema; Diabetic macular oedema; Wet Macular Degeneration; Diabetes Mellitus; Macular Degeneration; Retinal Vein Occlusion Details
Aflibercept BAT-86-5321; BAY-865321 Approved Regeneron Pharmaceuticals Inc, Bayer AG Eylea Mainland China Macular Degeneration; Macular Edema Bayer Australia Ltd 2011-11-18 Pseudoxanthoma Elasticum; Melanoma; Choroidal Neovascularization; Corneal Neovascularization; Diabetes Mellitus; Diabetic Retinopathy; Retinopathy of Prematurity; Retinal Vein Occlusion; Neoplasm Metastasis; Macular Degeneration; Retinal Degeneration; Vitreous Hemorrhage; Eye Diseases; Diabetes Complications; Retinal Detachment; Colorectal Neoplasms; Diabetes Mellitus, Type 1; Vitreoretinopathy, Proliferative; Diabetic macular oedema; Wet Macular Degeneration; Prostatic Neoplasms; Retinitis Pigmentosa; Myopia, Degenerative; Retinal Diseases; Central Serous Chorioretinopathy; Neoplasms; Telangiectasis; Diabetes Mellitus, Type 2; Glaucoma, Neovascular; Macular Edema; Cataract Details
Bevacizumab biosimilar (mAbixience) MB02; BEVZ-92; BEVZ92-MB02; AP-01 Approved Mabxience Alymsys United States Colorectal Neoplasms Amneal Pharmaceuticals Llc 2013-10-25 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ranibizumab biosimilar (CJSC Generium) GNR-067 Phase 1 Clinical Cjsc Generium Macular Degeneration Details
Colorectal cancer vaccine (Immunovo/Pepscan Therapeutics) Phase 1 Clinical Pepscan Systems Colorectal Neoplasms Details
Ranibizumab biosimilar (Reliance Life Sciences Group) R-TPR-024 Phase 3 Clinical Reliance Life Sciences Macular Degeneration Details
SCT-501(National Cancer Institute) SCT-501 Phase 2 Clinical National Cancer Institute Kidney Neoplasms Details
Ziv-aflibercept biosimiliar (Boan Biopharma) LY-01012; BA-1103 Phase 1 Clinical Shandong Boan Biotechnology Co Ltd Colorectal Neoplasms Details
Bevacizumab biosimilar (Gedeon Richter) Phase 1 Clinical Gedeon Richter Plc Neoplasms Details
Ranibizumab biosimilar (Xbrane) Phase 3 Clinical Xbrane Biopharma Macular Degeneration Details
Varisacumab R-84; GNR-011; AT-001-IBCG Phase 3 Clinical Peregrine, Ut Southwestern Medical Center Glioblastoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Aflibercept biosimilar (Amgen) ABP-938 Phase 2 Clinical Amgen Inc Macular Degeneration Details
Bevacizumab biosimilar (JHL Biotech) JHL-1149 Phase 1 Clinical JHL Biotech Neoplasms Details
Bevacizumab biosimilar (Synermore Biologics) SYN-050 Phase 1 Clinical Lonn Ryonn Pharma Ltd Neoplasms Details
Bevacizumab biosimilar(Guangdong Dongyangguang) Phase 1 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Shanghai Kangdai) Phase 1 Clinical Shanghai Kanda Bio-Technology Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Tanvex BioPharma) TX-16 Phase 1 Clinical Tanvex Biopharma Colorectal Neoplasms Details
Bevacizumab biosimilar (Huaota Biopharm) JS-501; HOT-1010 Phase 3 Clinical Shanghai Huaota Biopharmaceutical Co Ltd, Shanghai Junshi Biosciences Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar(Guilin Sanjin) Phase 1 Clinical Guilin Sanjin Pharmaceutical Co Ltd Macular Degeneration Details
Bevacizumab biosimilar(Bioxpress) BXT-2316 Clinical Bioxpress Therapeutics Sa Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Aflibercept biosimilar (CinnaGen) Phase 3 Clinical Cinnagen Macular Degeneration Details
Bevacizumab biosimilar(Shanghai Institute Of Biological Products) SIBP-04 Phase 1 Clinical Shanghai Institute Of Biological Products Co Ltd Details
Aflibercept biosimilar (Zein Bioteccnology) Phase 1 Clinical Zein Bioteccnology Co Ltd Diabetic macular oedema Details
IBI-324 IBI-324 Phase 1 Clinical Innovent Biologics (Usa), Inc Diabetic macular oedema Details
CLS-1002 CLS-1002 Phase 1 Clinical Clearside Biomedical Inc Macular Degeneration Details
Ranibizumab biosimilar (Pfenex) PF-582 Pfenex Details
Aflibercept biosimilar (Samsung Bioepis) SB-15 Phase 3 Clinical Samsung Bioepis Macular Degeneration Details
Aflibercept biosimilar (Sam Chun Dang Pharm) SCD-411 Sam Chun Dang Pharm Co Ltd Details
FYB-203 FYB-203 Formycon Details
Bevacizumab biosimilar (Beijing Science Sun/Beijing Lvzhu) K-11 Phase 1 Clinical Beijing Lvzhu Biological Technology Co Ltd, Beijing Science Sun Pharmaceutical Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Aflibercept biosimilar (Mabwell) 9-MW-0813; 9MW-0813; 9MW0813; 9-MW0813 Phase 3 Clinical Mabwell (Shanghai) Bioscience Co Ltd Diabetic macular oedema Details
CT-P42 CT-P42 Celltrion Details
Bevacizumab biosimilar(Laboratorios Sophia) PRO-169 Laboratorios Sophia Sa De Cv Details
Muparfostat sodium PI-88 Phase 3 Clinical Australian National University Carcinoma, Hepatocellular Details
DE-120 DE-120 Santen Details
AG-13958 AG-13958; AG-013958 Pfizer Inc Details
Abicipar pegol MP-0112; AGN-150998 Molecular Partners Details
Sevacizumab SIM-BD-0801; EPI-0030; BD-0801; TK-001; APX-003; 9MW0211; 9MW-0211; MW02; MW-02 Phase 3 Clinical Epitomics, Apexigen Inc Solid tumours; Carcinoma, Ovarian Epithelial; Wet Macular Degeneration; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
Ranibizumab biosimilar (Qilu Pharmaceutical) BCD-300; QL-1205 Phase 3 Clinical Qilu Pharmaceutical Co Ltd, Biocnd Wet Macular Degeneration; Macular Degeneration Details
Ranibizumab biosimilar (Chong Kun Dang Pharmaceutical) CKD-701 Chong Kun Dang Pharmaceutical Corp Details
Palomids P-529; P-52901; RES-529; SG-00529; Palomid-529 Diffusion Pharmaceuticals Details
MP-0250 MP-0250 Molecular Partners Details
AVA-001(Adverum biotechnologies) AVA-001 Adverum Biotechnologies Details
Bevasiranib Opko Health Details
Aflibercept/Rinucumab REGN-2176-3 Regeneron Pharmaceuticals Inc, Bayer AG Details
Aflibercept biosimilar (Momenta/Mylan) M-710; MYL-1701P Mylan Nv, Momenta Details
Aflibercept Biosimilar (Alteogen) ALT-L9 Phase 3 Clinical Alteogen Inc, Kissei Pharmaceutical Macular Degeneration Details
VEGF activator zinc finger protein SB-509; hVEGF-A Sangamo Biosciences Details
AZD-8601 mRNA-AZD-8601; AZD-8601 Astrazeneca Pharmaceutical Co Ltd, Moderna Inc Details
Aflibercept/Nesvacumab REGN 910-3 Regeneron Pharmaceuticals Inc Details
LMG-324 LMG-324 Alcon Details
Bevacizumab biosimilar(Jiangsu Aosaikang) ASK-1202; AMD-B; AK-3008 Phase 3 Clinical Jiangsu Aosaikang Pharmaceutical Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
SNN-0029 sNN-0029 Newron Pharmaceutical Details
acrizanib LHA-510 Alcon Details
XL-820 XL-820 Exelixis Details
Bevacizumab biosimilar (Boehringer Ingelheim) BI-695502 C.H. Boehringer Sohn Ag & Co. Kg Details
Vanucizumab RG-7221; RO-5520985; B800Z06O8K (UNII code) F. Hoffmann-La Roche Ltd Details
Bevacizumab biosimilar (Hualan Biological Engineering) WBP-264 Phase 3 Clinical Hualan Genetic Engineering Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ranibizumab biosimilar (Lupin) LUBT-010 Phase 3 Clinical Rubin Ltd Macular Degeneration Details
Aflibercept Biosimilar (Boan Biopharma/Luye Pharma) LY-09004; BA-9101; OT-702 Phase 3 Clinical Shandong Boan Biotechnology Co Ltd, Luye Pharma Group Ltd Wet Macular Degeneration; Macular Degeneration Details
Bevacizumab biosimilar (North China Pharmaceutical) MG-021 Phase 1 Clinical North China Pharmaceutical Company Ltd Colorectal Neoplasms; Macular Degeneration; Carcinoma, Non-Small-Cell Lung Details
BI-836880 BI-836880 Phase 1 Clinical Ablynx Squamous Cell Carcinoma of Head and Neck; Neoplasms; Wet Macular Degeneration; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Centus Biotherapeutics) FKB-238 Phase 3 Clinical Fujifilm Kyowa Kirin Biologics Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Dilpacimab ABT-165; DVD-Ig ABT-165 Phase 1 Clinical Abbvie Inc Solid tumours; Neoplasms Details
Bevacizumab biosimilar (Genor Biopharma) GB-222 Phase 3 Clinical Genor Biopharma Co Ltd Ovarian Neoplasms; Solid tumours; Breast Neoplasms; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Alphamab/R-Pharm) RPH-001 Phase 3 Clinical Suzhou Alphamab Co Ltd, R-Pharm Ovarian Neoplasms; Solid tumours; Breast Neoplasms; Colorectal Neoplasms Details
Bevacizumab biosimilar (Prestige BioPharma/Hanwha Biologics) HD-204 Phase 3 Clinical Hanwha Biologics Solid tumours; Ovarian Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Cipla BioTec) CBT-124 Phase 2 Clinical Cipla Gmbh Ovarian Neoplasms; Solid tumours; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ranibizumab biosimilar (Shanghai United Cell Biotechnology) Phase 1 Clinical Shanghai United Cell Biotechnology Co Ltd Macular Edema; Macular Degeneration Details
ALS-L1023 ALS-L1023 Phase 2 Clinical Angiolab Inc Non-alcoholic Fatty Liver Disease; Metabolic Syndrome; Macular Degeneration Details
Emvododstat PTC-299 Phase 3 Clinical Ptc Therapeutics Inc Pneumonia; Neoplasms; Neurofibromatosis 2; Coronavirus Disease 2019 (COVID-19); Central Nervous System Neoplasms; Brain Neoplasms; Breast Neoplasms; Coronavirus Infections; Leukemia, Myeloid, Acute; Sarcoma, Kaposi Details
Aflibercept Biosimilar(Alvotech Swiss) AVT-06 Phase 3 Clinical Alvotech Swiss Ag Macular Degeneration Details
OB-318 OB-318 Phase 1 Clinical Oneness Biotech Co Ltd Solid tumours; Carcinoma, Hepatocellular Details
Bevacizumab biosimilar (Fudan-Zhangjiang) Phase 3 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Colorectal Neoplasms; Macular Degeneration; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Eastern Biotech) JY-028 Phase 2 Clinical Beijing Eastern Biotech Co Ltd Wet Macular Degeneration; Colorectal Neoplasms; Macular Degeneration; Carcinoma, Non-Small-Cell Lung Details
ASKG-712 AM-712; ASKG-712 Phase 1 Clinical Askgene Pharma Wet Macular Degeneration; Macular Degeneration Details
Bevacizumab biosimilar(Zhejiang Teruisi Pharmaceutical) TRS-003 Phase 3 Clinical Zhejiang Teruisi Pharmaceutical Inc Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
TR-009 NOV-1501; ABL001-ABL Bio; ABL-001-ABL Bio; ES-104; CTX-009 Phase 2 Clinical Abl Bio Solid tumours; Bile Duct Neoplasms; Colorectal Neoplasms Details

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