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CD28H

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Cat. No. Species Product Description Structure Purity Feature
CDH-H52H3 Human Human CD28H / IGPR-1 Protein, His Tag
CDH-H52H3-structure
CDH-H52H3-sds
CDH-H5251 Human Human CD28H / IGPR-1 Protein, Fc Tag (MALS verified)
CDH-H5251-structure
CDH-H5251-sds
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Part of Bioactivity data

CDH-H5251-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human B7-H7, His Tag (Cat. No. B77-H52H5) on HIS1K Biosensor, can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with an affinity constant of 16.4 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
CDH-H5251-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Cynomolgus B7-H7, His Tag (Cat. No. B77-C52H3) on HIS1K Biosensor, can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with an affinity constant of 13.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

TMIGD2,IGPR1

Background

CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1,is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue,the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Clinical and Translational Updates

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